Document Detail

Cerebrovascular effects of high intracranial pressure after moderate hemorrhage.
MedLine Citation:
PMID:  9796606     Owner:  NLM     Status:  MEDLINE    
Patients with head injuries often develop increased intracranial pressure after hemorrhage. The authors studied the effect of moderate hemorrhage followed by elevated intracranial pressure on cerebrovascular variables. Cerebral blood flow in 13 pigs was measured with laser Doppler flowmetry, and cerebral venous blood gases were taken from the sagittal sinus. High intracranial pressure (80% of mean arterial pressure) was induced by infusion of artificial cerebrospinal fluid into the cisterna magna, and blood pressure was reduced by bleeding to a mean of 78% of the prebleeding values in eight pigs. Five pigs served as secondary controls. High intracranial pressure before hemorrhage caused a decrease in cerebral blood flow to 34% of the baseline values, a decrease in sagittal sinus oxygen saturation to 46%, and a decrease in cerebral perfusion pressure to 36%, but did not change cerebrovascular resistance. High intracranial pressure after hemorrhage decreased cerebral blood flow to 14% of baseline values. Sagittal sinus oxygen saturation decreased to 22%, cerebral perfusion pressure decreased to 30%, and the cerebrovascular resistance increased by 355%. The moderate hypotension after hemorrhage caused a considerable enhancement of the effects of high intracranial pressure on cerebral hemodynamics.
I R Rise; C Risöe; O J Kirkeby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  10     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-30     Citation Subset:  IM    
Institute for Surgical Research, The National Hospital, University of Oslo, Norway.
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MeSH Terms
Cerebral Hemorrhage / physiopathology*
Cerebrovascular Circulation*
Intracranial Hypertension / physiopathology*
Laser-Doppler Flowmetry
Oxygen Consumption
Prone Position
Supine Position
Vascular Resistance

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