| Cerebrovascular disease in symptomatic and asymptomatic patients with sickle cell anemia: screening with duplex transcranial Doppler US--correlation with MR imaging and MR angiography. | |
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MedLine Citation:
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PMID: 8105505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The authors evaluated the role of transcranial Doppler ultrasonography (US) in patients with sickle cell disease (SCD) and cerebrovascular disease. MATERIALS AND METHODS: Twenty-one patients with SCD and stroke (aged 3-22 years; mean age at stroke, 9 years) were evaluated with magnetic resonance (MR) imaging and duplex transcranial Doppler US with a 2-MHz transducer. Nineteen patients also underwent MR angiography. Forty-six asymptomatic patients with SCD were also evaluated with Doppler US, MR imaging, and MR angiography. RESULTS: The following transcranial Doppler US findings were correlated with cerebrovascular disease in patients with SCD: (a) maximum velocity in the ophthalmic artery (OA) of more than 35 cm/sec; (b) mean velocity in the middle cerebral artery (MCA) of more than 170 cm/sec; (c) resistive index in the OA of less than 50; (d) velocity in the OA greater than that of the ipsilateral MCA; and (e) maximum velocity in the posterior cerebral, vertebral, or basilar arteries greater than the maximum velocity in the MCA. CONCLUSION: Transcranial Doppler US scanning has great potential as an inexpensive, easily performed screening procedure for cerebrovascular disease in patients with SCD. |
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Authors:
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J J Seibert; S F Miller; R S Kirby; D L Becton; C A James; C M Glasier; A R Wilson; D L Kinder; D H Berry |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 189 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-18 Completed Date: 1993-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 457-66 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Arkansas Children's Hospital, Little Rock 72202-3591. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Sickle Cell / complications* Angiography Arterial Occlusive Diseases / diagnosis, radiography, ultrasonography Basilar Artery / pathology, ultrasonography Cerebral Angiography Cerebral Arteries / pathology, ultrasonography Cerebral Infarction / diagnosis, radiography, ultrasonography Cerebrovascular Disorders / complications, diagnosis*, radiography, ultrasonography* Child Child, Preschool Follow-Up Studies Humans Magnetic Resonance Imaging / methods* Prospective Studies Sensitivity and Specificity Ultrasonography, Doppler, Transcranial* Vertebral Artery / pathology, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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