| Cerebrotendinous xanthomatosis: treatments with simvastatin, lovastatin, and chenodeoxycholic acid in 3 siblings. | |
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MedLine Citation:
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PMID: 2006015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report 3 sisters treated for cerebrotendinous xanthomatosis. We treated one, with a severe neurologic form of the illness, with chenodeoxycholic acid, then lovastatin and simvastatin. These drugs had different efficacy and tolerance, but induced no clinical improvement. Her sisters, without neurologic symptoms, received chenodeoxycholic acid, which normalized the cholestanol level. Optimal treatment of this illness must begin before there is significant clinical symptomatology. |
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Authors:
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J Peynet; A Laurent; P De Liege; P Lecoz; P Gambert; A Legrand; J Mikol; A Warnet |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurology Volume: 41 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-25 Completed Date: 1991-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 434-6 Citation Subset: AIM; IM |
Affiliation:
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Laboratoire de Biochimie, Hospital Lariboisière, Paris. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticholesteremic Agents / therapeutic use Brain Diseases / drug therapy*, genetics, radiography Chenodeoxycholic Acid / therapeutic use* Female Humans Lovastatin / analogs & derivatives*, therapeutic use* Muscular Diseases / drug therapy, genetics, radiography Simvastatin Tendons* Tomography, X-Ray Computed Xanthomatosis / drug therapy*, genetics, radiography |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 474-25-9/Chenodeoxycholic Acid; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin |
| Comments/Corrections | |
Comment In:
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Neurology. 1994 Nov;44(11):2218
[PMID:
7970001
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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