Document Detail


Cerebrospinal monoamine metabolites and amino acid content in patients with parkinsonian syndrome and rats lesioned with MPP+.
MedLine Citation:
PMID:  7710669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monoamine metabolites and amino acid concentration in cerebrospinal fluid (CSF) of 33 untreated patients with parkinsonian syndrome, and 20 control patients without specific neurological symptoms have been compared with those obtained in cerebrospinal fluid of rats intrastriatally lesioned with 1-methyl-4-phenylpyridinium ion (MPP+) and sham operated animals. Homovanillic acid content was found to be significantly lower in patients with severe parkinsonism (motor score of UPDRS > 24), but not in patients with mild symptoms (motor score < or = 24). A correlation between the loss of striatal dopamine and the decrease in cerebrospinal homovanillic acid has been established in rats treated with MPP+. The extrapolation of these results to those obtained from human patients could be important in assessing the degree of striatal dopamine loss shown by humans with parkinsonian syndrome at the moment of clinical diagnosis. No significant differences were found between the other monoamine metabolites analyzed and free amino acid content in human and rat CSF.
Authors:
A Espino; S Ambrosio; R Bartrons; G Bendahan; M Calopa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. Parkinson's disease and dementia section     Volume:  7     ISSN:  0936-3076     ISO Abbreviation:  J Neural Transm Park Dis Dement Sect     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-17     Completed Date:  1995-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8914371     Medline TA:  J Neural Transm Park Dis Dement Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  167-76     Citation Subset:  IM    
Affiliation:
Department of Neurology, Hospital Prínceps d'Espanya, Spain.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenylpyridinium
Aged
Amino Acids / cerebrospinal fluid*
Animals
Biogenic Monoamines / cerebrospinal fluid,  metabolism*
Female
Homovanillic Acid / cerebrospinal fluid,  metabolism
Humans
Male
Middle Aged
Motor Activity
Parkinson Disease, Secondary / metabolism*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Monoamines; 306-08-1/Homovanillic Acid; 48134-75-4/1-Methyl-4-phenylpyridinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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