| Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. | |
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MedLine Citation:
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PMID: 20584616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrospinal fluid (CSF) urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) levels were measured in patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) by quantitative sandwich enzyme immunoassays. The CSF concentrations of uPA and MMP-9 were evaluated in 30 EOMA patients and 10 controls. The CSF uPA and MMP-9 levels of the EOMA patients were significantly higher than those of the controls (p<0.001). The positive detection values were 73% (22/30) and 86.7% (26/30) for uPA and MMP-9, respectively. The uPA detection was in correlation with headache duration (p=0.008) and stiff neck (p=0.048), while the MMP-9 was in correlation with CSF total protein (p=0.006), CSF leukocytosis (p=0.004) and CSF eosinophil numbers (p=0.02). CSF uPA and MMP-9 levels are potentially useful for the understanding of immunologic pathogenesis, for therapeutic targets, for the diagnosis of EOMA and for monitoring treatment efficacy. |
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Authors:
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Oranuch Sanpool; Pewpan M Intapan; Tongjit Thanchomnang; Taweesak Santivarangkana; Kanigar Niwattayakul; Verajit Chotmongkol; Wanchai Maleewong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-26 |
Journal Detail:
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Title: Cytokine Volume: 51 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 294-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Faculty of Medicine and Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Eosinophils / pathology* Female Humans Male Matrix Metalloproteinase 9 / cerebrospinal fluid* Meningitis / cerebrospinal fluid*, complications*, enzymology Middle Aged Strongylida Infections / cerebrospinal fluid*, complications*, enzymology Urokinase-Type Plasminogen Activator / cerebrospinal fluid* Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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