| Cerebrospinal fluid testing for the diagnosis of central nervous system infection. | |
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MedLine Citation:
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PMID: 10517923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The central nervous system (CNS) is susceptible to bacterial, viral, and fungal infections, and prion diseases. Examination of the cerebrospinal fluid (CSF) is crucial in diagnosing these infections. Cerebrospinal tests may directly identify an organism and its nucleic acid and surface constituents by culture, polymerase chain reaction (PCR), or antigen detection. Alternatively, antibody to an organism may be identified in CSF by enzyme-linked immunosorbent assay (ELISA), Western blot, or complement fixation assay. This article discusses how these CSF tests are performed and addresses the sensitivity and specificity of such tests for the diagnosis of selected CNS infections. |
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Authors:
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J R Zunt; C M Marra |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurologic clinics Volume: 17 ISSN: 0733-8619 ISO Abbreviation: Neurol Clin Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-13 Completed Date: 1999-12-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8219232 Medline TA: Neurol Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-89 Citation Subset: IM |
Affiliation:
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Acting Assistant Professor, Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98104, USA. jzunt@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Specificity
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immunology Central Nervous System Infections / cerebrospinal fluid*, immunology, microbiology Enzyme-Linked Immunosorbent Assay Humans Polymerase Chain Reaction / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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