Document Detail

Cerebrospinal fluid tenascin-C increases preceding the development of chronic shunt-dependent hydrocephalus after subarachnoid hemorrhage.
MedLine Citation:
PMID:  18323479     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The possible cause of chronic hydrocephalus after subarachnoid hemorrhage (SAH) has been reported to be meningeal fibrosis. We examined whether the induction of tenascin-C (TN-C), an extracellular matrix glycoprotein known to promote tissue fibrosis, was associated with chronic hydrocephalus after SAH. METHODS: We prospectively measured cerebrospinal fluid TN-C levels in 7 control patients with unruptured cerebral aneurysms and in 29 consecutive patients with aneurysmal SAH on days 1 to 12. RESULTS: Cerebrospinal fluid TN-C levels were less than the diagnostic threshold level in control patients but markedly increased after SAH. Higher TN-C levels were observed in patients with more severe SAH on admission CT, ventricular drainage for acute obstructive hydrocephalus, and a worse outcome. Independent of these factors, however, cerebrospinal fluid TN-C levels were significantly higher in patients with than without subsequent chronic shunt-dependent hydrocephalus on days 1 to 9. CONCLUSIONS: These findings suggest the possible involvement of TN-C in the development of chronic hydrocephalus after SAH and encourage further studies.
Hidenori Suzuki; Noriaki Kinoshita; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Waro Taki
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2008-03-06
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1610-2     Citation Subset:  IM    
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MeSH Terms
Biological Markers / analysis,  cerebrospinal fluid
Cerebrospinal Fluid Shunts
Chronic Disease / therapy
Extracellular Matrix / metabolism
Fibrosis / etiology,  metabolism*,  physiopathology
Hydrocephalus / cerebrospinal fluid*,  etiology*,  surgery
Meninges / metabolism*,  pathology,  physiopathology
Middle Aged
Predictive Value of Tests
Prospective Studies
Subarachnoid Hemorrhage / complications*
Tenascin / analysis,  cerebrospinal fluid*
Up-Regulation / physiology
Reg. No./Substance:
0/Biological Markers; 0/Tenascin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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