| Cerebrospinal fluid tau protein levels in schizophrenia. | |
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MedLine Citation:
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PMID: 12799749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased cerebrospinal fluid (CSF) tau protein levels are generally considered to provide a sensitive marker of neurodegenerative processes such as Alzheimer's disease (AD). Since a more pronounced cognitive decline has been described in older schizophrenic patients, it has been hypothesized that these patients might be at a higher risk of developing AD. CSF levels of total tau protein and tau protein phosphorylated at threonine 181 (phospho-tau) were determined among 19 older and younger patients with schizophrenia compared to 20 age-matched healthy controls. No significant differences in CSF total tau and phospho-tau levels arose between patients with schizophrenia and controls. Although our results do not exclude a progressive neurodegenerative pathology, they provide evidence against major neuronal degeneration such as an AD-related pathology associated with increased tau levels in schizophrenia. |
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Authors:
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Peter Schönknecht; Albrecht Hempel; Aoife Hunt; Ulrich Seidl; Martin Volkmann; Johannes Pantel; Johannes Schröder |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European archives of psychiatry and clinical neuroscience Volume: 253 ISSN: 0940-1334 ISO Abbreviation: Eur Arch Psychiatry Clin Neurosci Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-06-11 Completed Date: 2003-09-22 Revised Date: 2009-05-11 |
Medline Journal Info:
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Nlm Unique ID: 9103030 Medline TA: Eur Arch Psychiatry Clin Neurosci Country: Germany |
Other Details:
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Languages: eng Pagination: 100-2 Citation Subset: IM |
Affiliation:
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Section of Geriatric Psychiatry, University of Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Biological Markers / cerebrospinal fluid Case-Control Studies Female Humans Immunoblotting Immunoenzyme Techniques Male Middle Aged Phosphorylation Psychiatric Status Rating Scales Schizophrenia / cerebrospinal fluid* tau Proteins / cerebrospinal fluid*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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