Document Detail

Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.
MedLine Citation:
PMID:  2528321     Owner:  NLM     Status:  MEDLINE    
Dementia and brain atrophy are established features of a large proportion of patients with acquired immune deficiency syndrome (AIDS). To investigate a potential mechanism for atrophy in AIDS, we measured the concentration of the endogenous neurotoxin quinolinic acid in the cerebrospinal fluid of 10 patients with AIDS and found that they had 3-fold higher quinolinic acid concentrations than 9 age-matched control subjects: 53.8 +/- 10.7 pmol/ml versus 18.4 +/- 3.4 pmol/ml, respectively (p less than 0.005). It remains to be determined whether increased brain quinolinic acid concentrations are involved in the pathogenesis of the neuropathology of AIDS.
M P Heyes; D Rubinow; C Lane; S P Markey
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  26     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-03     Completed Date:  1989-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-7     Citation Subset:  IM; X    
Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, MD 20892.
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MeSH Terms
Acquired Immunodeficiency Syndrome / cerebrospinal fluid*
Pyridines / cerebrospinal fluid*
Quinolinic Acid
Quinolinic Acids / cerebrospinal fluid*
Tryptophan / metabolism*
Reg. No./Substance:
0/Pyridines; 0/Quinolinic Acids; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid

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