Document Detail

Cerebrospinal fluid outflow and intracranial pressure in hydrocephalic patients with external ventricular drainage.
MedLine Citation:
PMID:  19814755     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The aim of this study was to monitor the 24 h cerebrospinal fluid (CSF) outflow and intracranial pressure (ICP) in hydrocephalic adult patients with external ventricular drainage (EVD).
PATIENTS AND METHODS: Twelve patients (5M/7F) aged 30-69 years suffering from acute hydrocephalus requiring EVD were admitted in the neuro-intensive care unit. The CSF collecting bag was continuously weighted using a high-precision scale, the filtered output of which was fed at 1 Hz to a computer and converted to flow (Q'ext(csf)). ICP was also recorded.
RESULTS: One patient was excluded because more than 80% of the Q'ext(csf) data were rejected by the system. The mean +/- SD Q'ext(csf) and ICP were respectively 7.5 +/- 3.4 ml/h (range 1.6-12.1 ml/h) and 12.4 +/- 2.7 mmHg. Two patterns of Q'ext(csf) were identified: a continuous profile and a discontinuous one with numerous bursts frequently associated with manoeuvres such as cough or chest physiotherapy. The short-term variations of Q'ext(csf) and ICP were usually unrelated.
CONCLUSION: The study stresses the important inter and intra-subject variability of Q'ext(csf) in patients with EVD. The mean Q'ext(csf) is lower than the reference production rate (21 ml/h), raising the question of persistent CSF absorption and/or depressed secretion. The independent changes of Q'ext(csf) and ICP on the short term is likely to be explained by the pressure-volume characteristics of the intracranial space.
O Klein; B Demoulin; R T Jean Auque; G Audibert; C Sainte-Rose; J-C Marchal; F Marchal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-08
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  122     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-11-22     Revised Date:  2011-06-29    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  140-7     Citation Subset:  IM    
Copyright Information:
(c) 2009 The Authors Journal compilation (c) 2009 Blackwell Munksgaard.
Unit of Paediatric Neurosurgery and Department of Neurosurgery, Nancy University Hospital, 29 Avenue du Marchal de Lattre de Tassigny, Nancy Cedex, France.
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MeSH Terms
Acute Disease
Cerebrospinal Fluid / physiology*
Cerebrospinal Fluid Pressure / physiology
Hydrocephalus / physiopathology*,  surgery
Intracranial Pressure / physiology*
Middle Aged
Observer Variation

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