Document Detail

Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: age and sex effects and individual variability.
MedLine Citation:
PMID:  2417634     Owner:  NLM     Status:  MEDLINE    
Lumbar cerebrospinal fluid (CSF) was obtained from children during and following treatment for acute lymphoblastic leukemia (ALL). One hundred ninety-two CSF samples from 50 subjects, which were selected to minimize the effects of the disease and its treatment (i.e., to approach "normality" as closely as possible), were analyzed for the monoamine precursors tyrosine (Tyr) and tryptophan (Trp) and the metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). Levels of HVA (p less than 0.0001), 5-HIAA (p less than 0.002), and Tyr (p less than 0.05) decreased with age from 3 to 17 years. Significant correlations were observed between the acid metabolites HVA and 5-HIAA (r = 0.79) and between the amino acid precursors Tyr and Trp (r = 0.71). Within individuals, levels of all four compounds were relatively stable over time, with total mean coefficient of variation ranging from 20% to 25%. No significant sex differences for CSF levels of HVA, 5-HIAA, Tyr, or Trp were found. Assessment of CSF monoamine precursors and metabolites in children treated for ALL may provide a method for understanding the chronic effect of CNS trauma on the ontogeny of monoamine systems.
M A Riddle; G M Anderson; S McIntosh; D F Harcherik; B A Shaywitz; D J Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  21     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-13     Completed Date:  1986-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-83     Citation Subset:  IM    
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MeSH Terms
Age Factors
Child, Preschool
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Leukemia, Lymphoid / cerebrospinal fluid*,  therapy
Sex Factors
Tryptophan / cerebrospinal fluid*
Tyrosine / cerebrospinal fluid*
Grant Support
Reg. No./Substance:
306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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