Document Detail

Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder.
MedLine Citation:
PMID:  7527565     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid (CSF), plasma, and urinary monoamine metabolites were determined for 29 boys, aged 6-12, with attention-deficit hyperactivity disorder (ADHD). Levels of CSF 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG), the metabolites of serotonin, dopamine, and norepinephrine, respectively, correlated significantly with behavioral measures of aggression and impulsivity/hyperactivity. However, these correlations were in the unexpected direction; for example, CSF 5-HIAA correlated positively with the Brown-Goodwin Lifetime History of Aggression Scale. HVA in CSF was positively correlated with several measures of hyperactivity. The replicability of these findings, as well as possible socioenvironmental effects, and the predictive value of CSF monoamines in prepubertal hyperactivity are the subjects of ongoing study.
F X Castellanos; J Elia; M J Kruesi; C S Gulotta; I N Mefford; W Z Potter; G F Ritchie; J L Rapoport
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychiatry research     Volume:  52     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-01-09     Completed Date:  1995-01-09     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  305-16     Citation Subset:  IM    
Child Psychiatry Branch, National Institute of Mental Health (NIMH), Bethesda, MD 20892.
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MeSH Terms
Aggression / drug effects,  physiology,  psychology
Attention / drug effects,  physiology
Attention Deficit Disorder with Hyperactivity / cerebrospinal fluid*,  diagnosis,  drug therapy,  psychology
Dextroamphetamine / therapeutic use
Double-Blind Method
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Impulsive Behavior / cerebrospinal fluid,  diagnosis,  drug therapy,  psychology
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Methylphenidate / therapeutic use
Motor Activity / drug effects,  physiology
Neurotransmitter Agents / cerebrospinal fluid*
Reg. No./Substance:
0/Neurotransmitter Agents; 113-45-1/Methylphenidate; 306-08-1/Homovanillic Acid; 51-64-9/Dextroamphetamine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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