Document Detail

Cerebrospinal fluid monoamine metabolites in alcoholic patients who attempt suicide.
MedLine Citation:
PMID:  1691893     Owner:  NLM     Status:  MEDLINE    
Reduced cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid have been reported to be commonly associated with suicidal behaviour. Alcoholics are known to often manifest suicidal behaviour. Therefore, we compared cerebrospinal fluid levels of monoamine metabolites in alcoholics who had (n = 20) and had not (n = 108) attempted suicide and healthy volunteers (n = 30). There were no significant differences among the 3 groups for CSF levels of either 5-hydroxyindoleacetic acid, the dopamine metabolite homovanillic acid, norepinephrine, or the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol.
A Roy; D Lamparski; J De Jong; B Adinoff; B Ravitz; D T George; D Nutt; M Linnoila
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  81     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-05-29     Completed Date:  1990-05-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  58-61     Citation Subset:  IM    
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
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MeSH Terms
Alcoholism / cerebrospinal fluid*
Biogenic Monoamines / cerebrospinal fluid*
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Methoxyhydroxyphenylglycol / cerebrospinal fluid
Middle Aged
Norepinephrine / cerebrospinal fluid
Suicide, Attempted*
Reg. No./Substance:
0/Biogenic Monoamines; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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