Document Detail


Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
MedLine Citation:
PMID:  7542489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In brain, most L-tryptophan is metabolized to indoleamines, whereas in systemic tissues L-tryptophan is catabolized to kynurenine pathway metabolites. Among these latter compounds are: quinolinic acid, an N-methyl-D-aspartate receptor agonist; kynurenic acid, an antagonist of excitatory amino acid receptors that also reduces quinolinic acid-mediated neurotoxicity; and L-kynurenine, a possible convulsant. Because the metabolism of L-tryptophan through the kynurenine pathway is dependent upon adequate nutrition, we sought to determine whether the impaired nutrition characteristic of eating-disordered patients might be associated with specific disturbances in this metabolic pathway. Cerebrospinal fluid levels of L-tryptophan, quinolinic acid, kynurenic acid, L-kynurenine, and 5-hydroxyindoleacetic acid were measured in medication-free female patients meeting DSM-III-R criteria for either anorexia nervosa (n = 10) or normal-weight bulimia nervosa (n = 22), studied at varying stages of nutritional recovery. Eight healthy, normal-weight females served as a comparison group. Cerebrospinal fluid levels of kynurenic acid were significantly reduced in underweight anorectics, compared to normal females, but returned to normal values with restoration of normal body weight. Although cerebrospinal fluid quinolinic acid levels were not different from controls, the ratio of quinolinic acid to kynurenic acid was significantly increased during the underweight phase of anorexia nervosa. Furthermore, in the eating-disordered patients, kynurenic acid levels in cerebrospinal fluid correlated positively with percent-of-population average body weight.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M A Demitrack; M P Heyes; M Altemus; T A Pigott; P W Gold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  37     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-20     Citation Subset:  IM    
Affiliation:
Michigan Eating Disorders Program, University of Michigan Medical Center, Ann Arbor 48109-0118, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anorexia Nervosa / cerebrospinal fluid*
Body Weight / physiology
Brain / metabolism
Bulimia / cerebrospinal fluid*
Female
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Kynurenic Acid / cerebrospinal fluid
Kynurenine / cerebrospinal fluid*
Quinolinic Acid / cerebrospinal fluid
Thinness / cerebrospinal fluid
Tryptophan / cerebrospinal fluid
Chemical
Reg. No./Substance:
343-65-7/Kynurenine; 492-27-3/Kynurenic Acid; 54-16-0/Hydroxyindoleacetic Acid; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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