| Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases. | |
| | |
MedLine Citation:
|
PMID: 8051562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nitric oxide has been proposed to mediate cytotoxic effects in inflammatory diseases. To investigate the possibility that overproduction of nitric oxide might play a role in the neuropathology of inflammatory and noninflammatory neurological diseases, we compared levels of the markers of nitric oxide, nitrite plus nitrate, in the CSF of controls with those in patients with various neurologic diseases, including Huntington's and Alzheimer's disease, amyotrophic lateral sclerosis, and HIV infection. We found that there were no significant increases in the CSF levels of these nitric oxide metabolites, even in patients infected with HIV or in monkeys infected with poliovirus, both of which have significantly elevated levels of the neurotoxin quinolinic acid and the marker of macrophage activation, neopterin. However, CSF quinolinic acid, neopterin, and nitrite/nitrate levels were significantly increased in a small group of patients with bacterial and viral meningitis. |
| | |
Authors:
|
S Milstien; N Sakai; B J Brew; C Krieger; J H Vickers; K Saito; M P Heyes |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of neurochemistry Volume: 63 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1994 Sep |
Date Detail:
|
Created Date: 1994-09-08 Completed Date: 1994-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1178-80 Citation Subset: IM; X |
Affiliation:
|
Laboratory of Neurochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
cerebrospinal fluid Amyotrophic Lateral Sclerosis / cerebrospinal fluid Animals Biopterin / analogs & derivatives, cerebrospinal fluid HIV Infections / cerebrospinal fluid Humans Huntington Disease / cerebrospinal fluid Macaca mulatta Neopterin Nervous System Diseases / cerebrospinal fluid* Nitrates / cerebrospinal fluid* Nitric Oxide / metabolism Nitrites / cerebrospinal fluid* Quinolinic Acid / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
|
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide; 22150-76-1/Biopterin; 670-65-5/Neopterin; 89-00-9/Quinolinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vit...
Next Document: Increase in rat adrenal phenylethanolamine N-methyltransferase mRNA level caused by immobilization s...