| Cerebrospinal fluid lactate dehydrogenase in infants with perinatal asphyxia. | |
| | |
MedLine Citation:
|
PMID: 7390027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cerebrospinal fluid (CSF) lactate dehydrogenase was determined in 19 control infants without asphyxia (Group I), 24 infants with perinatal asphyxia (Group II), and 26 asphyxiated infants with seizures (Group III). Mean birthweights, gestational ages, CSF glucose, protein and red blood cells, and the ages at which the lumbar punctures were performed were not significantly different among the three groups. Mean CSF lactate dehydrogenase was significantly higher in Group III than in Groups I and II. Isoenzyme patterns indicated that the origin of the CSF lactate dehydrogenase was neuronal tissue, or a plasma transudate from increased permeability of the blood-brain barrier. There were 10 deaths due to anoxic encephalopathy in Group III, but none in Groups I or II. Follow-up of survivors at 10 to 30 months of age revealed neurological sequelae in three infants in Group I, two in Group II and five in Group III. Mean CSF lactate dehydrogenase in those with sequelae had not been significantly different from that of normal survivors; however, the mean was significantly higher in infants who died with anoxic encephalopathy compared with normal infants. These data indicate that CSF lactate dehydrogenase is significantly elevated in infants with fatal anoxic brain damage, and suggest that determinations may be of prognostic value in non-fatal cerebral hypoxia. |
| | |
Authors:
|
R T Hall; P B Kulkarni; M B Sheehan; P G Rhodes |
Related Documents
:
|
18201217 - Neuropathology of a 4-month-old infant born to a woman with phenylketonuria. 16602007 - Cns-manifestation of aspergillosis in an extremely low-birth-weight infant. 19944837 - Advances in near-infrared spectroscopy to study the brain of the preterm and term neonate. 9809667 - Infant cold exposure changes fos expression to acute cold stimulation in adult hypothal... 20863437 - Congenital infections with trypanosoma cruzi or toxoplasma gondii are associated with d... 9525537 - Polychlorinated biphenyls in blood plasma among swedish female fish consumers in relati... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Developmental medicine and child neurology Volume: 22 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 1980 Jun |
Date Detail:
|
Created Date: 1980-09-23 Completed Date: 1980-09-23 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 300-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asphyxia Neonatorum
/
enzymology* Birth Weight Child Development Erythrocytes / enzymology Gestational Age Humans Hypoxia, Brain / enzymology Infant, Newborn L-Lactate Dehydrogenase / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
|
EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical correction of equinus deformity in cerebral palsy.
Next Document: Cerebral oxidative metabolism in perinatal post-hemorrhagic hydrocephalus.