| Cerebrospinal fluid interleukin 1-beta and tumor necrosis factor concentrations and outcome from neonatal gram-negative enteric bacillary meningitis. | |
| | |
MedLine Citation:
|
PMID: 2652086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Concentrations of interleukin 1-beta and tumor necrosis factor in cerebrospinal fluid (CSF) of 42 neonates with Gram-negative enteric bacillary meningitis were determined and correlated with outcome and other CSF indices. At the time of diagnosis interleukin 1-beta was detected in CSF of 40 infants and peak concentrations correlated significantly with outcome from disease. Days of interleukin 1-beta concentrations of greater than 200 pg/ml or greater than or equal to 20 pg/ml were significantly correlated with days that CSF cultures were positive and that K1 antigen and endotoxin were detected in CSF. Tumor necrosis factor activity was detected in CSF of 25 of 27 infants; there was no correlation between outcome and CSF tumor necrosis factor concentrations. The results provide a possible rationale for therapeutic intervention to improve outcome. |
| | |
Authors:
|
G H McCracken; M M Mustafa; O Ramilo; K D Olsen; R C Risser |
Related Documents
:
|
1486086 - Pink hypopyon: a sign of serratia marcescens endophthalmitis. 6464736 - Neonatal meningitis in nigerian infants. 20593986 - The treatment and outcome of postmeningitic subdural empyema in infants. 1877266 - Aztreonam-induced myelosuppression during treatment of pseudomonas aeruginosa pneumonia. 21801246 - A th1/th2-associated chemokine imbalance during infancy in children developing eczema, ... 17052286 - Necrotising enterocolitis hospitalisations among neonates in the united states. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Pediatric infectious disease journal Volume: 8 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1989 Mar |
Date Detail:
|
Created Date: 1989-05-26 Completed Date: 1989-05-26 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 155-9 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Enterobacteriaceae Infections
/
immunology* Escherichia coli Infections / immunology Humans Infant, Newborn Interleukin-1 / cerebrospinal fluid* Meningitis / immunology* Prognosis Salmonella Infections / immunology Tumor Necrosis Factor-alpha / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-1; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of enteric coagulase-negative staphylococci from neonates with necrotizing enterocolitis.
Next Document: Heredity and diseases of the organs of the urinary system: results and prospects of research