Document Detail


Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
MedLine Citation:
PMID:  20299968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A subset of HIV-infected patients, termed 'elite' viral controllers, maintain undetectable plasma HIV RNA levels in the absence of therapy. In this group, host-mediated viral control may be accompanied by chronic systemic inflammation. It is unknown whether either infection or chronic inflammation is present within the central nervous system of these individuals.
METHODS: Cross-sectional analysis compared cerebrospinal fluid (CSF) HIV RNA and biomarkers of intrathecal inflammation in eight controllers (plasma HIV RNA levels <50 copies/ml) with 26 HIV-uninfected individuals, 25 untreated individuals HIV-infected, viremic individuals, and 23 HIV-infected individuals with treatment-mediated viral suppression (plasma HIV RNA levels <50 copies/ml).
RESULTS: All controllers had CSF HIV RNA levels below 2.5 copies/ml. CSF white blood cell (WBC) counts and CSF: plasma albumin ratios in the controllers were similar to those in both HIV-uninfected individuals and antiretroviral therapy-suppressed HIV-infected individuals. CSF neopterin, MCP-1, and IP-10 concentrations were also not different in the controllers from either HIV-uninfected or treated HIV-infected individuals.
CONCLUSION: The character of CSF HIV infection and degree of immunoactivation in controllers is comparable to that of HIV-uninfected and antiretroviral therapy-suppressed HIV-infected individuals, but distinct from that of untreated, viremic HIV-infected individuals.
Authors:
John C Probasco; Steven G Deeks; Evelyn Lee; Rebecca Hoh; Peter W Hunt; Teri Liegler; Richard W Price; Serena S Spudich
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  24     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1001-5     Citation Subset:  IM; X    
Affiliation:
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
CD4 Lymphocyte Count
Cross-Sectional Studies
Female
HIV Infections / cerebrospinal fluid*,  drug therapy,  virology
HIV Seronegativity
HIV-1 / genetics*
Humans
Inflammation / cerebrospinal fluid
Male
Middle Aged
Myelitis / cerebrospinal fluid,  diagnosis
RNA, Viral / cerebrospinal fluid*
Spinal Cord / virology*
Viral Load
Grant Support
ID/Acronym/Agency:
AI27763/AI/NIAID NIH HHS; K23MH74466/MH/NIMH NIH HHS; K24AI069994/AI/NIAID NIH HHS; MH59037/MH/NIMH NIH HHS; R01MH62701/MH/NIMH NIH HHS; R01NS37660/NS/NINDS NIH HHS; UL1 RR024131-01/RR/NCRR NIH HHS; UL1RR024131/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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