Document Detail


Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes.
MedLine Citation:
PMID:  22205595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypocretin (Hcrt) has been implicated in the control of motor activity and in respiration and cardiovascular changes. Loss of Hcrt in narcolepsy is linked to sleepiness and to cataplexy, a sudden loss of muscle tone which is triggered by sudden strong emotions. In the current study we have compared the effects of treadmill running, to yard play on cerebrospinal fluid (CSF) Hcrt level in normal dogs. We find that treadmill locomotion, at a wide range of speeds, does not increase Hcrt level beyond baseline, whereas yard play produces a substantial increase in Hcrt, even though both activities produce comparable increases in heart rate, respiration and body temperature. We conclude that motor and cardiovascular changes are not sufficient to elevate CSF levels of Hcrt and we hypothesize that the emotional aspects of yard play account for the observed increase in Hcrt.
Authors:
M-F Wu; R Nienhuis; N Maidment; H A Lam; J M Siegel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-11-07
Journal Detail:
Title:  Archives italiennes de biologie     Volume:  149     ISSN:  0003-9829     ISO Abbreviation:  Arch Ital Biol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-29     Completed Date:  2012-06-21     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0372441     Medline TA:  Arch Ital Biol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  492-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of California, Los Angeles, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blood Pressure / physiology*
Body Temperature / physiology*
Dogs
Exercise Test
Male
Perylene / analogs & derivatives*,  cerebrospinal fluid
Physical Conditioning, Animal / physiology*
Play and Playthings*
Quinones / cerebrospinal fluid*
Radioimmunoassay
Respiration*
Grant Support
ID/Acronym/Agency:
MH64109/MH/NIMH NIH HHS; NS14610/NS/NINDS NIH HHS; R01 MH064109/MH/NIMH NIH HHS; R01 NS014610/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Quinones; 198-55-0/Perylene; 77029-83-5/hypocrellin A
Comments/Corrections

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