| Cerebrospinal fluid hypocretin (orexin) levels are elevated by play but are not raised by exercise and its associated heart rate, blood pressure, respiration or body temperature changes. | |
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MedLine Citation:
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PMID: 22205595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypocretin (Hcrt) has been implicated in the control of motor activity and in respiration and cardiovascular changes. Loss of Hcrt in narcolepsy is linked to sleepiness and to cataplexy, a sudden loss of muscle tone which is triggered by sudden strong emotions. In the current study we have compared the effects of treadmill running, to yard play on cerebrospinal fluid (CSF) Hcrt level in normal dogs. We find that treadmill locomotion, at a wide range of speeds, does not increase Hcrt level beyond baseline, whereas yard play produces a substantial increase in Hcrt, even though both activities produce comparable increases in heart rate, respiration and body temperature. We conclude that motor and cardiovascular changes are not sufficient to elevate CSF levels of Hcrt and we hypothesize that the emotional aspects of yard play account for the observed increase in Hcrt. |
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Authors:
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M-F Wu; R Nienhuis; N Maidment; H A Lam; J M Siegel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-11-07 |
Journal Detail:
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Title: Archives italiennes de biologie Volume: 149 ISSN: 0003-9829 ISO Abbreviation: Arch Ital Biol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-29 Completed Date: 2012-06-21 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 0372441 Medline TA: Arch Ital Biol Country: Italy |
Other Details:
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Languages: eng Pagination: 492-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of California, Los Angeles, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Pressure / physiology* Body Temperature / physiology* Dogs Exercise Test Male Perylene / analogs & derivatives*, cerebrospinal fluid Physical Conditioning, Animal / physiology* Play and Playthings* Quinones / cerebrospinal fluid* Radioimmunoassay Respiration* |
| Grant Support | |
ID/Acronym/Agency:
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MH64109/MH/NIMH NIH HHS; NS14610/NS/NINDS NIH HHS; R01 MH064109/MH/NIMH NIH HHS; R01 NS014610/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Quinones; 198-55-0/Perylene; 77029-83-5/hypocrellin A |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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