| Cerebrospinal fluid glutamate levels in chronic migraine. | |
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MedLine Citation:
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PMID: 15315529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both preclinical and clinical data link glutamate to the migraine pathophisiology. Altered plasma, platelets and cerebrospinal (CSF) glutamate levels have been reported in migraine patients. Chronic migraine is comorbid with several conditions. It has been recently shown chronic migraine comorbidity with fibromyalgia. The objective of this study was to study cerebrospinal fluid glutamate levels in chronic migraine patients with and without fibromyalgia. We studied 20 chronic migraine patients, with and without fibromyalgia, compared to age-sex matched controls. CSF glutamate levels were measured by HPLC. CSF glutamate demonstrated significantly higher levels in patients with fibromyalgia compared to those without fibromyalgia. Patients overall had higher CSF glutamate levels than controls. Mean pain score correlated with glutamate levels in chronic migraine patients. Tender points, the hallmark of fibromyalgia, can be considered as pressure allodynia, and is probably mediated by central sensitization, with increase in CSF glutamate levels. We postulate chronic migraine patients with fibromyalgia, in addition to have more disabling headaches, suffer from a more severe central sensitization process. This subtype of patients may respond to medications modulating glutamate receptors. Headache intensity correlate with glutamate levels in chronic migraine patients. |
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Authors:
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M F P Peres; E Zukerman; C A Senne Soares; E O Alonso; B F C Santos; M H W Faulhaber |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: 24 ISSN: 0333-1024 ISO Abbreviation: Cephalalgia Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-18 Completed Date: 2004-10-29 Revised Date: 2008-02-11 |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: England |
Other Details:
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Languages: eng Pagination: 735-9 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Blackwell Publishing Ltd |
Affiliation:
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Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromatography, High Pressure Liquid Chronic Disease Female Fibromyalgia / cerebrospinal fluid*, complications Glutamic Acid / cerebrospinal fluid* Humans Male Middle Aged Migraine Disorders / cerebrospinal fluid*, complications |
| Chemical | |
Reg. No./Substance:
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56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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