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Cerebrospinal fluid findings in geriatric patients from 2008 to 2011.
MedLine Citation:
PMID:  22903361     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The chemical composition of the cerebrospinal fluid (CSF) is age-dependent. METHODS: Routine CSF parameters, the indications for lumbar puncture (LP), and the most frequent complications were retrospectively studied in patients older (n = 167) and younger (n = 36) than 65 years. RESULTS: In the absence of meningeal inflammation, the mean CSF lactate level of patients older than 65 years was slightly but significantly higher than the mean CSF lactate level of younger patients. The lactate level of patients with otherwise normal CSF findings correlated significantly with the age of the patients. In the absence of meningeal inflammation, the CSF-to-serum albumin ratio (Q(Albumin)) was significantly higher in older patients than in younger ones. The most frequent indication for LP, suspected infection of the central nervous system (CNS) (n = 110), was confirmed in 12.7% of patients. The only LP complication documented was headache in two patients. CONCLUSIONS: Elevations of Q(Albumin) and CSF lactate levels appear to be nonspecific findings in elderly patients. Suspected infections, the most frequent indication for LP, were confirmed by CSF analysis in more than 10% of patients. The very low complication rate of LP makes it a very valuable tool in the diagnostic routine for older patients with CNS diseases.
Authors:
M Djukic; D Schulz; H Schmidt; P Lange; R Nau
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-19
Journal Detail:
Title:  Zeitschrift fur Gerontologie und Geriatrie     Volume:  -     ISSN:  1435-1269     ISO Abbreviation:  Z Gerontol Geriatr     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506215     Medline TA:  Z Gerontol Geriatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neuropathology, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany, mdjukic@gwdg.de.
Vernacular Title:
Lumbalpunktionsbefunde bei geriatrischen Patienten im Zeitraum von 2008-2011.
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