| Cerebrospinal fluid detection of enterovirus genome in ALS: a study of 242 patients and 354 controls. | |
| | |
MedLine Citation:
|
PMID: 19900148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Detection of enterovirus (EV) in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) has been reported on post mortem central nervous system tissues. In cases of persistent infection, it is very likely that the EV genome might be detected in the cerebrospinal fluid (CSF). A study was conducted in seven French amyotrophic lateral sclerosis (ALS) centres between 1997 and 2002. A total of 242 ALS patients and 354 age- and sex-matched controls (non-ALS patients) were enrolled. A sensitive RT-PCR method was performed on the CSF to assess the presence of EV RNA; 14.5% of ALS patients were positive compared to 7.6% of controls (chi(2) value, 5.31; p = 0.02). Although EV infection has a seasonal pattern, we observed no seasonality in positive detection of the EV genome among ALS patients. There was no significant relationship among ALS patients between the initial clinical form or survival and the result of the RT-PCR. These findings suggest a relationship between the presence of EV sequences in CSF and ALS. Our study is consistent with the hypothesis that persistent EV infection can be one of the multiple factors involved in the development of ALS. |
| | |
Authors:
|
Nadia Vandenberghe; Nicolas Leveque; Philippe Corcia; Véronique Brunaud-Danel; Emmanuelle Salort-Campana; Gérard Besson; Christine Tranchant; Pierre Clavelou; Frédérique Beaulieux; René Ecochard; Christophe Vial; Emmanuel Broussolle; Bruno Lina |
Related Documents
:
|
19961048 - The neural cell adhesion molecule (ncam) present in the cerebrospinal fluid of multiple... 7752998 - Significance of lymphoblasts in cerebrospinal fluid in newly diagnosed pediatric acute ... 6147948 - Dopamine-beta-hydroxylase and acetylcholinesterase activities of cerebrospinal fluid in... 10155408 - The use of intraperitoneal infusion for the outpatient treatment of hypovolemia in soma... 2606048 - Cerebrospinal fluid/serum lactic acid in febrile convulsions. 2644718 - A clinical evaluation of ultrasonography in the diagnosis of acute appendicitis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Volume: 11 ISSN: 1471-180X ISO Abbreviation: Amyotroph Lateral Scler Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-03 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101283386 Medline TA: Amyotroph Lateral Scler Country: England |
Other Details:
|
Languages: eng Pagination: 277-82 Citation Subset: IM |
Affiliation:
|
Hospices Civils de Lyon, Centre SLA de Lyon (Service d'Electroneuromyographie et Service de Neurologie C), Hôpital Neurologique Pierre Wertheimer, Lyon, France. nadia.vandenberghe@chu-lyon.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amyotrophic Lateral Sclerosis / cerebrospinal fluid*, mortality, virology* Case-Control Studies Enterovirus / genetics* Female Genome, Viral / physiology* Humans Male Middle Aged RNA, Viral / cerebrospinal fluid* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Advanced twin abdominal pregnancy: diagnostic and therapeutic challenges.
Next Document: Relationships between child, parent and community characteristics and weight status among young chil...