Document Detail


Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimer's disease.
MedLine Citation:
PMID:  20551690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebrospinal fluid (CSF) biomarkers play an important role in the differential diagnosis of neurodegenerative diseases such as Alzheimer's disease (AD) and its postulated precursor stage mild cognitive impairment (MCI). While CSF tau protein, phospho-tau protein and beta-amyloid have become part of the diagnostic process in clinical routine, the importance of several other biomarkers remains quite unclear. Among these, amino acids and metabolic compounds have been studied in clinical conditions mostly other than AD and, to our knowledge, never in MCI. In patients with AD (n = 14) and MCI (n = 13) we now determined CSF levels of 36 different amino acids and metabolic compounds by high-performance liquid chromatography. We found that 8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI. As most of these amino acids and metabolic compounds are functionally important for brain-specific metabolic processes, neurotransmitter pathways or compensatory mechanisms, our findings might reflect these changes occurring within the brain of patients with MCI and those who developed manifest AD.
Authors:
Elmar Kaiser; Peter Schoenknecht; Stefan Kassner; Wulf Hildebrandt; Ralf Kinscherf; Johannes Schroeder
Publication Detail:
Type:  Journal Article     Date:  2010-05-05
Journal Detail:
Title:  Neuro-degenerative diseases     Volume:  7     ISSN:  1660-2862     ISO Abbreviation:  Neurodegener Dis     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-16     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189034     Medline TA:  Neurodegener Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Affiliation:
Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany. elmar.kaiser@med.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / cerebrospinal fluid*,  diagnosis,  physiopathology*
Amino Acids / cerebrospinal fluid*,  metabolism,  physiology
Biological Markers / cerebrospinal fluid,  metabolism
Cognition Disorders / cerebrospinal fluid*,  diagnosis,  physiopathology*
Female
Humans
Male
Middle Aged
Nerve Tissue Proteins / cerebrospinal fluid,  metabolism,  physiology
Neurochemistry / methods
Predictive Value of Tests
Sensitivity and Specificity
Up-Regulation / physiology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biological Markers; 0/Nerve Tissue Proteins

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