| Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimer's disease. | |
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MedLine Citation:
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PMID: 20551690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrospinal fluid (CSF) biomarkers play an important role in the differential diagnosis of neurodegenerative diseases such as Alzheimer's disease (AD) and its postulated precursor stage mild cognitive impairment (MCI). While CSF tau protein, phospho-tau protein and beta-amyloid have become part of the diagnostic process in clinical routine, the importance of several other biomarkers remains quite unclear. Among these, amino acids and metabolic compounds have been studied in clinical conditions mostly other than AD and, to our knowledge, never in MCI. In patients with AD (n = 14) and MCI (n = 13) we now determined CSF levels of 36 different amino acids and metabolic compounds by high-performance liquid chromatography. We found that 8 out of 36 amino acids (urea, threonine, glutamate, citrulline, alpha-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI. As most of these amino acids and metabolic compounds are functionally important for brain-specific metabolic processes, neurotransmitter pathways or compensatory mechanisms, our findings might reflect these changes occurring within the brain of patients with MCI and those who developed manifest AD. |
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Authors:
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Elmar Kaiser; Peter Schoenknecht; Stefan Kassner; Wulf Hildebrandt; Ralf Kinscherf; Johannes Schroeder |
Publication Detail:
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Type: Journal Article Date: 2010-05-05 |
Journal Detail:
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Title: Neuro-degenerative diseases Volume: 7 ISSN: 1660-2862 ISO Abbreviation: Neurodegener Dis Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-16 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101189034 Medline TA: Neurodegener Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 251-9 Citation Subset: IM |
Copyright Information:
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2010 S. Karger AG, Basel. |
Affiliation:
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Section of Geriatric Psychiatry, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany. elmar.kaiser@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / cerebrospinal fluid*, diagnosis, physiopathology* Amino Acids / cerebrospinal fluid*, metabolism, physiology Biological Markers / cerebrospinal fluid, metabolism Cognition Disorders / cerebrospinal fluid*, diagnosis, physiopathology* Female Humans Male Middle Aged Nerve Tissue Proteins / cerebrospinal fluid, metabolism, physiology Neurochemistry / methods Predictive Value of Tests Sensitivity and Specificity Up-Regulation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biological Markers; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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