| Cerebrospinal fluid changes in the excitatory amino acids concentration caused by the standard treatment of acute lymphoblastic leukaemia in children do not correlate with their later cognitive functioning. | |
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MedLine Citation:
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PMID: 20446226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to ascertain whether changes in the concentrations of cerebrospinal fluid excitatory amino acids (EAAs) contribute to neurotoxicity of the standard acute lymphoblastic leukaemia (ALL) treatment protocols. We found a statistically significant increase in glutamate and aspartate in 12 ALL patients during their treatment. Cognitive functioning was examined in all patients at an average of 3.7 years after the disease diagnosis. Importantly, the levels of EAAs during the therapy were not correlated with the results of the cognitive test. This study suggests that standard ALL treatment-induced neurotoxicity may not lead to persistent neurocognitive deficits. |
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Authors:
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P T Protas; K Muszynska-Roslan; A Holownia; A Grabowska; M Krawczuk-Rybak; J J Braszko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-05 |
Journal Detail:
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Title: Neuropediatrics Volume: 40 ISSN: 1439-1899 ISO Abbreviation: Neuropediatrics Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8101187 Medline TA: Neuropediatrics Country: Germany |
Other Details:
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Languages: eng Pagination: 295-7 Citation Subset: IM |
Copyright Information:
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Copyright Georg Thieme Verlag KG Stuttgart New York. |
Affiliation:
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Departament of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland. piotrp15@wp.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Combined Chemotherapy Protocols / adverse effects Child Child, Preschool Cognition / drug effects, physiology* Excitatory Amino Acids / cerebrospinal fluid* Female Humans Male Neuropsychological Tests Precursor Cell Lymphoblastic Leukemia-Lymphoma / cerebrospinal fluid*, complications, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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