Document Detail

Cerebrospinal fluid changes in the excitatory amino acids concentration caused by the standard treatment of acute lymphoblastic leukaemia in children do not correlate with their later cognitive functioning.
MedLine Citation:
PMID:  20446226     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to ascertain whether changes in the concentrations of cerebrospinal fluid excitatory amino acids (EAAs) contribute to neurotoxicity of the standard acute lymphoblastic leukaemia (ALL) treatment protocols. We found a statistically significant increase in glutamate and aspartate in 12 ALL patients during their treatment. Cognitive functioning was examined in all patients at an average of 3.7 years after the disease diagnosis. Importantly, the levels of EAAs during the therapy were not correlated with the results of the cognitive test. This study suggests that standard ALL treatment-induced neurotoxicity may not lead to persistent neurocognitive deficits.
P T Protas; K Muszynska-Roslan; A Holownia; A Grabowska; M Krawczuk-Rybak; J J Braszko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-05
Journal Detail:
Title:  Neuropediatrics     Volume:  40     ISSN:  1439-1899     ISO Abbreviation:  Neuropediatrics     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  295-7     Citation Subset:  IM    
Copyright Information:
Copyright Georg Thieme Verlag KG Stuttgart New York.
Departament of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Child, Preschool
Cognition / drug effects,  physiology*
Excitatory Amino Acids / cerebrospinal fluid*
Neuropsychological Tests
Precursor Cell Lymphoblastic Leukemia-Lymphoma / cerebrospinal fluid*,  complications,  drug therapy*
Reg. No./Substance:
0/Excitatory Amino Acids

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