Document Detail

Cerebrospinal fluid anti-cerebellar soluble lectin antibodies in human immunodeficiency virus type 1 infection.
MedLine Citation:
PMID:  1732284     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid samples from 14 human immunodeficiency type 1 (HIV-1) seropositive patients in various stages of HIV infection were tested for the presence of autoantibodies to an endogenous manose-binding protein, the cerebellar soluble lectin (CSL), which has recently been found to be detected in a high proportion of patients with multiple sclerosis. An immunoblotting test was used with rat CSL as antigen. Seven patients were positive for anti-CSL and seven were negative. The seven anti-CSL-positive patients had signs of intrathecal immunoglobulin G production measured as an elevated IgG index, while the seven anti-CSL-negative patients had a normal IgG index. There was no apparent relation between infectious stage and the presence of anti-CSL. Immunological reactions such as anti-CSL autoantibodies may be a similar pathogenic mechanism in HIV and multiple sclerosis brain disease.
L Hagberg; G Norkrans; J P Zanetta; S Lehmann; T Bergström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  36     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM; X    
Department of Infectious Diseases, University of Göteborg, Sweden.
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MeSH Terms
Acquired Immunodeficiency Syndrome / cerebrospinal fluid,  immunology*
Autoantibodies / cerebrospinal fluid*
Cerebellum / immunology*
Lectins / immunology*
Middle Aged
Reg. No./Substance:
0/Autoantibodies; 0/Lectins

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