Document Detail

Cerebrospinal fluid analyses in migraine patients and controls.
MedLine Citation:
PMID:  8706112     Owner:  NLM     Status:  MEDLINE    
To investigate the role of central neurotransmitters in the pathogenesis of migraine, we measured cerebrospinal fluid (CSF) levels of certain amino acids (glycine, taurine, glutamine) and metabolites of biogenic amines (5-hydroxyindoleacetic acid and homovanillic acid) in 38 migraine patients and compared them with the levels from 10 headache-free controls. The levels of taurine, glycine and glutamine were significantly higher in the migraine patients (p < 0.0001 for taurine and glycine; p < 0.0009 for glutamine); there were no significant differences among the three migraine subgroups (infrequent migraine, frequent migraine and transformed migraine). In seven patients subsequently treated with divalproex sodium, CSF taurine levels decreased significantly from pretreatment baseline values. These data support the concept that migraine is at least in part a disorder of central neurotransmission.
J F Rothrock; K R Mar; T L Yaksh; A Golbeck; A C Moore
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  15     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-09-12     Completed Date:  1996-09-12     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
San Diego (UCSD) Headache Center, University of California, USA.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Glutamine / cerebrospinal fluid
Glycine / cerebrospinal fluid
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Middle Aged
Migraine Disorders / cerebrospinal fluid*
Neurotransmitter Agents / cerebrospinal fluid*
Taurine / cerebrospinal fluid
Reg. No./Substance:
0/Neurotransmitter Agents; 107-35-7/Taurine; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 56-40-6/Glycine; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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