Document Detail


Cerebrospinal fluid β-amyloid(1-42) correlates with rate of progression in Alzheimer's disease.
MedLine Citation:
PMID:  22460296     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Emerging treatment options targeting the pathogenetic mechanisms in Alzheimer's disease (AD) and the need to monitor efficacy during treatment trials necessitate the use of biomarkers, which not only may facilitate early and reliable diagnosis, but may also assist in the stratification of patient populations according to their rate of progression. The objective of the present study is to examine whether demographic and cerebrospinal fluid (CSF) parameters at initial evaluation [total tau, tau phosphorylated at threonine-181 and amyloid-beta(1-42) (Aβ42)] can be used to discriminate between slow and rapid progressors in patients with AD. A total of 74 AD patients were included in the study. Patients recruited were divided into slow and rapid progressors according to their Mini-Mental Status Examination (MMSE) score decline before evaluation. Patients with a drop rate of >4/year were considered rapid progressors. Commercially available ELISA kits were used for measuring CSF biomarkers. Comparisons were performed using analysis of covariance. Significantly lower Aβ42 levels in the CSF were found in rapid (mean 392 pg/ml) as compared to slow progressors (mean 453 pg/ml), with a p value of 0.042. The results of the present study suggest that levels of the Aβ42 peptide may be related to the rate of disease progression. Further studies with a prospective design are needed in order to test the possible predictive value of CSF Aβ42 analysis.
Authors:
George S Vlachos; George P Paraskevas; Dimitris Naoumis; Elizabeth Kapaki
Related Documents :
21747616 - Epidemiologic study of malassezia yeasts in patients with malassezia folliculitis by 26...
9778616 - Residual disease and presence of human papillomavirus after conization.
22883816 - Types, outcome and risk factors of stroke in tribal patients.
10565746 - Detection of high-grade prostatic intraepithelial neoplasia with the five-region biopsy...
25239496 - Long-term treatment with tenofovir in asian-american chronic hepatitis b patients is as...
21778676 - Serum resistin as a novel marker of erythropoietin resistance in nondiabetic patients o...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-30
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  -     ISSN:  1435-1463     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Athens, Eginition Hospital, Athens, Attiki, Greece, drgevgr@yahoo.gr.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Frankfurt early intervention program FFIP for preschool aged children with autism spectrum disor...
Next Document:  Methylphenidate (MPH) promotes visual cortical activation in healthy adults in a cued visuomotor tas...