Document Detail

Cerebrospinal fluid amino acids in relation to neurological status in experimental portal-systemic encephalopathy.
MedLine Citation:
PMID:  1749365     Owner:  NLM     Status:  MEDLINE    
Using an indwelling cisterna magna catheter technique, serial CSF samples were analyzed for amino acid content in rats at various stages of portal-systemic encephalopathy resulting from ammonium acetate administration following portacaval anastomosis. Anastomosis alone resulted in increased CSF concentrations of glutamine, tyrosine, phenylalanine, glutamate and alanine. GABA levels, on the other hand were not significantly changed. Onset of severe neurological symptoms following ammonium acetate administration resulted in selectively increased CSF alanine. Other amino acids were not further increased at severe stages of encephalopathy. Increased CSF alanine probably results from increased glutamine transamination in the brains of portacaval shunted rats.
G Therrien; R F Butterworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolic brain disease     Volume:  6     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-74     Citation Subset:  IM    
Laboratory of Neurochemistry, André-Viallet Clinical Research Center, Hôpital Saint-Luc (University of Montreal), Quebec, Canada.
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MeSH Terms
Adenosine Triphosphate / cerebrospinal fluid
Amino Acids / cerebrospinal fluid*
Chromatography, High Pressure Liquid
Hepatic Encephalopathy / cerebrospinal fluid*,  physiopathology
Rats, Inbred Strains
Spectrometry, Fluorescence
o-Phthalaldehyde / diagnostic use
Reg. No./Substance:
0/Amino Acids; 56-65-5/Adenosine Triphosphate; 643-79-8/o-Phthalaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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