| Cerebrospinal fluid acid-base balance in newborns. | |
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MedLine Citation:
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PMID: 6808889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In adults, cerebrospinal fluid (CSF) acid-base balance is an important determinant of cerebral blood flow, ventilatory drive, and state of consciousness. Sixteen lumbar punctures were performed on newborns (mean gestational age, 33.8 weeks; range, 26 to 44 weeks). The mean CSF pH was 7.366 units, 0.036 less than the mean capillary blood pH (NS). The mean CSF arterial carbon dioxide tension (PCO2) was 40.3 mm Hg, 6.7 greater than the mean blood PCO2 (p less than 0.01). The mean bicarbonate ion concentration in CSF was 21.8 mEq/L, 1.2 greater than that in blood (NS). Acid-base determinations in CSF of neonates with intraventricular hemorrhage did not differ significantly from those of neonates with otherwise normal CSF. These acid-base values are similar to those found in adults and did not vary with gestational age, suggesting that mechanisms to establish this acid-base gradient are developed by 26 weeks' gestation. |
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Authors:
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M C Hermansen; P H Ellison |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 11 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-09-10 Completed Date: 1982-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 344-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium* Bicarbonates / blood Carbon Dioxide / blood Gestational Age Humans Hydrogen-Ion Concentration Infant, Newborn Infant, Newborn, Diseases / blood, cerebrospinal fluid* Nervous System Diseases / blood, cerebrospinal fluid* Partial Pressure |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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