| Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders. | |
| | |
MedLine Citation:
|
PMID: 22982200 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Recent findings document numerous interactions between neronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II), anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R= -0.51, p<0.0009) but not with SAS and TAS-20. The finding indicates that decreased level of S100B in CSF is related to increased symptoms of depression in the NIND patients. |
| | |
Authors:
|
Tomas Uher; Petr Bob |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
|
Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry & UHSL, 1(st) Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Neurology, 1(st) Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: uhertomas@hotmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Voxel-based morphometry of disgust proneness.
Next Document: Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophr...