| Cerebrospinal fluid N-acetyl neuraminic acid estimation for early diagnosis and differentiation of bacterial meningitis. | |
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MedLine Citation:
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PMID: 1752679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrospinal fluid (CSF) analysis for free, bound and total N-Acetyl Neuraminic Acid (NANA) as well as serum NANA was done in 68 patients of bacterial meningitis, of which 37 cases were of pyrogenic meningitis and 31 of tuberculous meningitis. Ten patients were included in the control group. The free NANA levels were increased in only pyogenic meningitis, independent of protein levels but the bound form increased with the increase in CSF proteins. The increase of free NANA in CSF of pyogenic meningitis patients was not related to the cell count or sugar content in CSF or to the duration or severity of illness. This finding can be of great help in differentiating cases of pyogenic meningitis, particularly partially treated patients, who may have ambiguous pictures of CSF analysis, from the cases of tuberculous meningitis. |
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Authors:
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A Darbari; N R Bhandari; B K Agrawal; S A Bhambal |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Indian pediatrics Volume: 28 ISSN: 0019-6061 ISO Abbreviation: Indian Pediatr Publication Date: 1991 May |
Date Detail:
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Created Date: 1992-01-29 Completed Date: 1992-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: INDIA |
Other Details:
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Languages: eng Pagination: 513-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Biochemistry, Gandhi Medical College, Bhopal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
/
blood,
cerebrospinal fluid*,
diagnosis Child Diagnosis, Differential Humans Meningitis / blood, cerebrospinal fluid*, diagnosis N-Acetylneuraminic Acid Reference Values Sialic Acids / blood, cerebrospinal fluid* Time Factors Tuberculosis, Meningeal / blood, cerebrospinal fluid*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Sialic Acids; 131-48-6/N-Acetylneuraminic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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