| Cerebrospinal fluid D-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients. | |
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MedLine Citation:
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PMID: 18261886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-Methyl D-aspartate (NMDA)-receptor hypofunction has been implicated in the pathophysiology of schizophrenia and D-serine and glycine add-on therapy to antipsychotics has shown beneficial effects in schizophrenic patients. Nevertheless, previous studies have not shown consistently altered D-serine concentrations in cerebrospinal fluid (CSF) of schizophrenic patients. To confirm and extend these results, CSF concentrations of both endogenous NMDA-receptor co-agonists d-serine and glycine and their common precursor L-serine were analyzed simultaneously in 17 healthy controls and 19 schizophrenic patients before and 6 weeks after daily olanzapine (10 mg) treatment. CSF D-serine, L-serine and glycine concentrations and their relative ratios were similar between schizophrenic patients and controls and no differences were observed before and after olanzapine therapy. Thus, the NMDA-receptor hypofunction hypothesis in schizophrenia is not explained by olanzapine therapy-dependent absolute or relative decreases in CSF D-serine and glycine concentrations in this series of male patients, thereby not providing convenient markers for the disorder. |
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Authors:
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Sabine A Fuchs; Martina M J De Barse; Floor E Scheepers; Wiepke Cahn; Lambertus Dorland; Monique G de Sain-van der Velden; Leo W J Klomp; Ruud Berger; René S Kahn; Tom J de Koning |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-07 |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 18 ISSN: 0924-977X ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-03-18 Completed Date: 2008-07-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 333-8 Citation Subset: IM |
Affiliation:
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Department of Metabolic and Endocrine Diseases and Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. S.Fuchs@umcutrecht.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / therapeutic use* Benzodiazepines / therapeutic use* Glycine / cerebrospinal fluid* Humans Male Middle Aged Schizophrenia / cerebrospinal fluid*, drug therapy* Serine / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 56-40-6/Glycine; 56-45-1/Serine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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