Document Detail


Cerebrospinal fluid D-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients.
MedLine Citation:
PMID:  18261886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-Methyl D-aspartate (NMDA)-receptor hypofunction has been implicated in the pathophysiology of schizophrenia and D-serine and glycine add-on therapy to antipsychotics has shown beneficial effects in schizophrenic patients. Nevertheless, previous studies have not shown consistently altered D-serine concentrations in cerebrospinal fluid (CSF) of schizophrenic patients. To confirm and extend these results, CSF concentrations of both endogenous NMDA-receptor co-agonists d-serine and glycine and their common precursor L-serine were analyzed simultaneously in 17 healthy controls and 19 schizophrenic patients before and 6 weeks after daily olanzapine (10 mg) treatment. CSF D-serine, L-serine and glycine concentrations and their relative ratios were similar between schizophrenic patients and controls and no differences were observed before and after olanzapine therapy. Thus, the NMDA-receptor hypofunction hypothesis in schizophrenia is not explained by olanzapine therapy-dependent absolute or relative decreases in CSF D-serine and glycine concentrations in this series of male patients, thereby not providing convenient markers for the disorder.
Authors:
Sabine A Fuchs; Martina M J De Barse; Floor E Scheepers; Wiepke Cahn; Lambertus Dorland; Monique G de Sain-van der Velden; Leo W J Klomp; Ruud Berger; René S Kahn; Tom J de Koning
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-07
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  18     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-07-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  333-8     Citation Subset:  IM    
Affiliation:
Department of Metabolic and Endocrine Diseases and Department of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. S.Fuchs@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / therapeutic use*
Benzodiazepines / therapeutic use*
Glycine / cerebrospinal fluid*
Humans
Male
Middle Aged
Schizophrenia / cerebrospinal fluid*,  drug therapy*
Serine / cerebrospinal fluid*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 56-40-6/Glycine; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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