Document Detail


Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in the pediatric opsoclonus-myoclonus syndrome.
MedLine Citation:
PMID:  7531417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the purported role of central monoamine disturbances in the pathophysiology of the opsoclonus-myoclonus syndrome, the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid were measured in cerebrospinal fluid samples from 27 affected children and 47 age- and gender-matched control subjects by high-pressure liquid chromatography with electrochemical detection. 5-Hydroxyindoleacetic acid and homovanillic acid concentrations in the cerebrospinal fluid were approximately 30 to 40% lower in opsoclonus-myoclonus patients compared to control subjects, and the normal inverse correlation between age and monoamine metabolite concentrations in the cerebrospinal fluid of control subjects was not found in opsoclonus-myoclonus patients. Patients with the lowest values were less than 4 years old, and a subgroup had extremely low levels, but differences in older children were not significant. Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid and homovanillic acid were more positively correlated in control subjects than in opsoclonus-myoclonus patients. None of the patients exhibited high levels of monoamine metabolites. Homovanillic acid levels were slightly lower in the cerebrospinal fluid of patients receiving corticotropin or steroids at the time of lumbar puncture. Clinical variables that could be excluded were paraneoplastic etiology, anesthetic for lumbar puncture, syndrome duration, age at onset, gender, response to steroids, length of time until initiation of corticotropin or steroids, presence of seizures, opsoclonus, and functional impairment. These data suggest a disturbance and possible altered ontogeny of serotonin or dopamine neurotransmission in a subpopulation of children with opsoclonus-myoclonus with low cerebrospinal fluid levels of 5-hydroxyindoleacetic acid and homovanillic acid.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M R Pranzatelli; Y Huang; E Tate; M Stanley; M J Noetzel; S M Gospe; K Banasiak
Related Documents :
3258017 - Histamine metabolites in cerebrospinal fluid of the rhesus monkey (macaca mulatta): cis...
971447 - 14c-homovanillic acid in the cerebrospinal fluid of parkinsonian patients after intrave...
911677 - 5-hydroxytryptamine and tryptamine pathways in scleroderma.
2416297 - Selective antidepressants and cerebrospinal fluid. lack of specificity on norepinephrin...
2879077 - Rapid method for micro-analysis of endogenous amino acid neurotransmitters in brain per...
18852337 - Gestational diabetes mellitus upsets the proportion of fatty acids in umbilical arteria...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  37     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-07     Completed Date:  1995-03-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Affiliation:
Department of Neurology, George Washington University, Washington, DC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Child
Child, Preschool
Chromatography, High Pressure Liquid
Electrochemistry
Female
Homovanillic Acid / cerebrospinal fluid*
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Infant
Male
Myoclonus / cerebrospinal fluid*,  drug therapy
Ocular Motility Disorders / cerebrospinal fluid*,  drug therapy
Prospective Studies
Regression Analysis
Syndrome
Grant Support
ID/Acronym/Agency:
FD-U-000746-01/02/FD/FDA HHS; MH-41847/MH/NIMH NIH HHS; MH-42242/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of tamoxifen on potential doubling time of human breast cancer cell line determined by image...
Next Document:  Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the...