Document Detail

Cerebrospinal fluid 5-hydroxyindolacetic acid and aggression: a critical reappraisal of the clinical data.
MedLine Citation:
PMID:  8675967     Owner:  NLM     Status:  MEDLINE    
Over the past 15 years several clinical studies have been published dealing with the hypothesis that disturbances in central serotonergic functioning could be related to outward directed aggression and impulsivity. Close reading of the 22 relevant reports, however, raises doubt about the unequivocality of the results across diagnostic boundaries and in comparison with normal controls. Only eight of the studies are methodologically acceptable and seem to support the hypothesis. Taking all data together, it is concluded that some relationship exists between decreased serotonin metabolism, as reflected by lowered cerebrospinal fluid 5-hydroxyindolacetic acid, and certain aspects of aggressive behavior in a subgroup of young, male, personality-disordered subjects with seriously deviant behavior.
S Tuinier; W M Verhoeven; H M van Praag
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  10     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-08-13     Completed Date:  1996-08-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  147-56     Citation Subset:  IM    
Vincent van Gogh Institute for Psychiatry, Department of Biological Psychiatry, Venray, The Netherlands.
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MeSH Terms
Behavior / drug effects
Depression / metabolism*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Serotonin / metabolism*
Statistics as Topic*
Reg. No./Substance:
50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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