Document Detail

Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: reciprocal relationships with impulsive aggression in human subjects.
MedLine Citation:
PMID:  20069438     Owner:  NLM     Status:  MEDLINE    
While the relationship between cerebrospinal fluid 5-HIAA (CSF 5-HIAA) and aggression is typically reported as inverse, studies of some groups of aggressive individuals demonstrate a positive (or no) relationship, between these two variables. It is possible that simultaneous examination of both CSF 5-HIAA and CSF homovanillic acid (HVA), which co-vary in human subjects may clarify differences in reported findings in different groups of aggressive individuals. CSF 5-HIAA and CSF HVA concentrations were simultaneously examined in 60 healthy human subjects (40 with personality disorder and 20 healthy controls) and were correlated with measures of aggression and impulsivity. CSF 5-HIAA concentrations correlated positively, and CSF HVA concentrations correlated inversely, with a composite measure of impulsive aggression in all subjects as well as in the personality disordered subjects. The CSF 5-HIAA findings are consistent with those demonstrating reduced post-synaptic 5-HT receptor responsiveness to 5-HT agent challenge and suggest differences in the pathophysiology between different groups of subjects with aggressive behavior, particularly with regard to severity of aggressive behavior.
Emil F Coccaro; Royce Lee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  117     ISSN:  1435-1463     ISO Abbreviation:  J Neural Transm     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  241-8     Citation Subset:  IM    
Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, 5841, South Maryland Avenue, Chicago, IL 60637, USA.
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MeSH Terms
Aggression / physiology*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Impulsive Behavior / cerebrospinal fluid*
Personality Disorders / cerebrospinal fluid*
Psychological Tests
Regression Analysis
Spinal Puncture
Grant Support
Reg. No./Substance:
306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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