Document Detail

Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis.
MedLine Citation:
PMID:  23041403     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were observed in NMO patients. However, concentration of cerebrospinal fluid (CSF) IL-21 in MS and NMO patients still remain unknown.
OBJECT: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity.
METHODS: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16).
RESULTS: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027).
CONCLUSIONS: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO.
Aimin Wu; Xiaonan Zhong; Honghao Wang; Wen Xu; Chen Cheng; Yongqiang Dai; Jian Bao; Wei Qiu; Zhengqi Lu; Xueqiang Hu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  39     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-01-04     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  813-20     Citation Subset:  IM    
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MeSH Terms
Antibodies, Antinuclear / blood
Antigens, Nuclear / blood
Complement System Proteins / metabolism
Disability Evaluation
Enzyme-Linked Immunosorbent Assay
Immunoglobulin G / blood
Interleukins / cerebrospinal fluid*
Linear Models
Middle Aged
Multiple Sclerosis / blood,  cerebrospinal fluid*,  diagnosis
Neuromyelitis Optica / blood,  cerebrospinal fluid*,  diagnosis
Young Adult
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antigens, Nuclear; 0/Immunoglobulin G; 0/Interleukins; 0/interleukin-21; 9007-36-7/Complement System Proteins

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