| Cerebrospinal Fluid IL-21 Levels in Neuromyelitis Optica and Multiple Sclerosis. | |
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MedLine Citation:
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PMID: 23041403 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were observed in NMO patients. However, concentration of cerebrospinal fluid (CSF) IL-21 in MS and NMO patients still remain unknown. Object: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity. Methods: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16). Results: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027). Conclusions: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO. |
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Authors:
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Aimin Wu; Xiaonan Zhong; Honghao Wang; Wen Xu; Chen Cheng; Yongqiang Dai; Jian Bao; Wei Qiu; Zhengqi Lu; Xueqiang Hu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 39 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 813-20 Citation Subset: IM |
Affiliation:
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Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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