| Cerebrospinal fluid ferritin level, a sensitive diagnostic test in late-presenting subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 20719531 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The workup of patients with suspected subarachnoid hemorrhage (SAH) presenting late is complicated by a loss of diagnostic sensitivity of computed tomography (CT) brain imaging and cerebrospinal fluid (CSF) bilirubin levels. In this prospective longitudinal study of CSF ferritin levels in SAH, serial CSF samples from 14 patients with aneurysmal SAH requiring extraventricular drainage (EVD) were collected. The control group comprised 44 patients presenting with headache suspicious of SAH. Nine patients underwent a traumatic spinal tap. CSF ferritin levels were significantly higher in the patients with SAH compared with controls (P < .0001). The upper reference range of CSF ferritin is 12 ng/mL, and there was no significant difference between the traumatic and normal spinal taps (mean, 9.0 ng/mL vs 3.9 ng/mL; P = .59). CSF ferritin levels increased after SAH, from an average of 65 ng/mL on day 1 to 1750 ng/mL on day 11 (P < .01). Both the Fisher and Columbia CT scores were significantly correlated with CSF ferritin level. The increas in CSF ferritin level after SAH and possibly may provide additional diagnostic information in patients with suspected SAH who present late to the clinic. |
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Authors:
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Axel Petzold; Viki Worthington; Ian Appleby; Mary E Kerr; Neil Kitchen; Martin Smith |
Publication Detail:
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Type: Journal Article Date: 2010-08-17 |
Journal Detail:
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Title: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Volume: 20 ISSN: 1532-8511 ISO Abbreviation: J Stroke Cerebrovasc Dis Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111633 Medline TA: J Stroke Cerebrovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 489-93 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 National Stroke Association. All rights reserved. |
Affiliation:
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Department of Neuroimmunology, University College London Institute of Neurology, London, UK; Tavistock Intensive Care Unit, National Hospital for Neurology and Neurosurgery, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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