Document Detail


Cerebrospinal fluid ferritin level, a sensitive diagnostic test in late-presenting subarachnoid hemorrhage.
MedLine Citation:
PMID:  20719531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The workup of patients with suspected subarachnoid hemorrhage (SAH) presenting late is complicated by a loss of diagnostic sensitivity of computed tomography (CT) brain imaging and cerebrospinal fluid (CSF) bilirubin levels. In this prospective longitudinal study of CSF ferritin levels in SAH, serial CSF samples from 14 patients with aneurysmal SAH requiring extraventricular drainage (EVD) were collected. The control group comprised 44 patients presenting with headache suspicious of SAH. Nine patients underwent a traumatic spinal tap. CSF ferritin levels were significantly higher in the patients with SAH compared with controls (P < .0001). The upper reference range of CSF ferritin is 12 ng/mL, and there was no significant difference between the traumatic and normal spinal taps (mean, 9.0 ng/mL vs 3.9 ng/mL; P = .59). CSF ferritin levels increased after SAH, from an average of 65 ng/mL on day 1 to 1750 ng/mL on day 11 (P < .01). Both the Fisher and Columbia CT scores were significantly correlated with CSF ferritin level. The increase in CSF ferritin level after SAH and possibly may provide additional diagnostic information in patients with suspected SAH who present late to the clinic.
Authors:
Axel Petzold; Viki Worthington; Ian Appleby; Mary E Kerr; Neil Kitchen; Martin Smith
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-17
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  20     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-03-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 National Stroke Association. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / cerebrospinal fluid
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Ferritins / cerebrospinal fluid*
Humans
Linear Models
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Spinal Puncture
Subarachnoid Hemorrhage / cerebrospinal fluid,  diagnosis*,  radiography,  therapy
Time Factors
Tomography, X-Ray Computed
Up-Regulation
Young Adult
Grant Support
ID/Acronym/Agency:
G0701458//Medical Research Council; R01 NR004339-01A2/NR/NINR NIH HHS; R01NR0433/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-73-2/Ferritins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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