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Cerebrospinal Fluid Biomarkers in Mild Cognitive Impairment and Dementia.
MedLine Citation:
PMID:  19815980     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Given the magnitude of the public health problem of dementia in the elderly, there is a pressing need for research, development, and timely application of biomarkers that will identify latent and prodromal illness as well as dementia. Although identification of risk factors and neuroimaging measures will remain key to these efforts, this review focuses on recent progress in the discovery, validation, and standardization of cerebrospinal fluid (CSF) biomarkers, small molecules and macromolecules whose CSF concentration can aid in diagnosis at different stages of disease as well as in assessment of disease progression and response to therapeutics. A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly.
Authors:
Joshua A Sonnen; Kathleen S Montine; Joseph F Quinn; John C S Breitner; Thomas J Montine
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-10-8
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA.
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