| Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients. | |
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MedLine Citation:
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PMID: 20800240 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Hypertensive (HT) patients are at higher risk of cognitive decline than normotensive individuals, because high blood pressure is a risk factor for mild cognitive deterioration. In this study cardio- and cerebrovascular reactivity along with cognitive performance was assessed on newly diagnosed HT patients. METHODS: Diagnosis of hypertension was based on international recommendations. None of the patients had diabetes, and all of them had normal cerebral CT scan. Eighty-one patients (43.5±10.2 years, male/female ratio: 42/39) were compared with 94 healthy controls (44±9.4 years, male/female ratio: 50/44). In both groups continuous, non-invasive and simultaneous monitoring of cerebral and cardiac hemodynamical parameters were recorded during head-up tilt table testing (HUTT). Reaction time, attention and memory skills, anxiety and depression rate were determined by neuropsychological tests. RESULTS: During HUTT significant differences were found in certain cardiovascular parameters (blood pressure, total peripheral resistance index, stroke index), but no differences were detected in cerebral blood flow velocity. While there was no significant difference in reaction time between the two groups, tests estimating short-term memory (Digit Span Test) differed significantly. Moreover, sum of standardized test scores was significantly lower, while anxiety level was significantly increased in HT patients compared to controls. CONCLUSION: Decrease in neuropsychological performance along with alterations of cardiovascular parameters is an early manifestation of hypertension. Aim for an early intervention and accurate treatment is crucial for preventing further impairments. |
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Authors:
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Katalin Réka Kovács; Csilla Cecília Szekeres; Zoltán Bajkó; Krisztina Csapó; Sándor Molnár; László Oláh; Mária Tünde Magyar; Dániel Bereczki; László Kardos; Pál Soltész; Andrea Burainé Bojtor; László Csiba |
Publication Detail:
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Type: Journal Article Date: 2010-08-30 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 299 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 120-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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