| Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. | |
| | |
MedLine Citation:
|
PMID: 18640784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence. |
| | |
Authors:
|
Jiska S Peper; Rachel M Brouwer; Hugo G Schnack; G Caroline M van Baal; Marieke van Leeuwen; Stéphanie M van den Berg; Henriëtte A Delemarre-Van de Waal; Andrew L Janke; D Louis Collins; Alan C Evans; Dorret I Boomsma; René S Kahn; Hilleke E Hulshoff Pol |
Related Documents
:
|
10490174 - Long-term stability of postpalatoplasty perceptual speech ratings: a prospective study. 8680264 - Guidelines on the audiologist's role in occupational and environmental hearing conserva... 6120394 - Cerebral ventricular size in twins discordant for schizophrenia. 18049964 - Toward a standard description of hearing loss. 968544 - Massive intraperitoneal hemorrhage from ruptured corpus luteum during anticoagulant the... 12454964 - Fetal magnetoencephalography in intrauterine growth retarded pregnancies. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2008-07-21 |
Journal Detail:
|
Title: Psychoneuroendocrinology Volume: 33 ISSN: 0306-4530 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-08-04 Completed Date: 2008-11-13 Revised Date: 2008-12-02 |
Medline Journal Info:
|
Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
|
Languages: eng Pagination: 909-15 Citation Subset: IM |
Affiliation:
|
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. j.s.peper@umcutrecht.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain
/
radiography Cerebral Cortex / growth & development* Child Female Humans Luteinizing Hormone / blood, urine* Male Puberty, Precocious / blood, physiopathology, radiography, urine* Registries Twins / blood, physiology, urine |
| Chemical | |
Reg. No./Substance:
|
9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study.
Next Document: Sex differences in the cortisol response to awakening in recent onset psychosis.