Document Detail

Cerebral white matter in early puberty is associated with luteinizing hormone concentrations.
MedLine Citation:
PMID:  18640784     Owner:  NLM     Status:  MEDLINE    
Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Volumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence.
Jiska S Peper; Rachel M Brouwer; Hugo G Schnack; G Caroline M van Baal; Marieke van Leeuwen; Stéphanie M van den Berg; Henriëtte A Delemarre-Van de Waal; Andrew L Janke; D Louis Collins; Alan C Evans; Dorret I Boomsma; René S Kahn; Hilleke E Hulshoff Pol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2008-07-21
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  33     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-11-13     Revised Date:  2008-12-02    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  909-15     Citation Subset:  IM    
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
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MeSH Terms
Brain / radiography
Cerebral Cortex / growth & development*
Luteinizing Hormone / blood,  urine*
Puberty, Precocious / blood,  physiopathology,  radiography,  urine*
Twins / blood,  physiology,  urine
Reg. No./Substance:
9002-67-9/Luteinizing Hormone

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