| Cerebral ventricle-brain ratio in monozygotic twins discordant and concordant for schizophrenia. | |
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MedLine Citation:
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PMID: 9789887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Several studies on monozygotic twins discordant for schizophrenia showed that the cerebral ventricle-brain ratio (VBR) was larger in the twins with schizophrenia, as compared with the corresponding normal twins. 2. The results suggest that the difference of the VBR of the discordant twins was larger than that of the concordant twins of schizophrenia. 3. The authors studied the VBR in four monozygotic twin pairs discordant and four monozygotic twin pairs concordant for schizophrenia by computerized tomography. 4. In the discordant twins, all pairs showed that the VBR of the normal twins was smaller than that of the corresponding twins with schizophrenia. 5. The difference of the VBR of the discordant twins and that of the concordant twins of schizophrenia was not statistically different using Mann-Whitney U test. 6. The preliminary results suggest that the VBR enlargement in schizophrenia is not genetically controlled in monozygotic twins either discordant or concordant for schizophrenia. 7. In monozygotic concordant twins, the brain pathology may be heterogeneous. |
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Authors:
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K Ohara; H D Xu; T Matsunaga; D S Xu; X Q Huang; G F Gu; K Ohara; Z C Wang |
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Publication Detail:
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Type: Journal Article; Twin Study |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 22 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1999-01-05 Completed Date: 1999-01-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1043-50 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anthropometry Cerebral Ventricles / anatomy & histology*, pathology Female Humans Male Schizophrenia / genetics*, physiopathology Twins, Monozygotic / genetics, psychology* |
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