Document Detail

Cerebral venous thrombosis during pregnancy in the setting of type I antithrombin deficiency: case report and literature review.
MedLine Citation:
PMID:  21134627     Owner:  NLM     Status:  In-Process    
Inherited antithrombin deficiency is estimated to carry a 50% risk of a venous thrombotic complication during each pregnancy and puerperium. We present a case of a female with heterozygous type I antithrombin deficiency who presented with a central nervous system transverse sinus thrombosis in the third trimester of pregnancy despite the use of therapeutic doses of low molecular weight heparin, as venous thromboembolic prophylaxis, since conception. A successful pregnancy outcome was achieved with the combined use of therapeutic anticoagulation and regular plasma-derived antithrombin concentrate infusions to normalize her antithrombin levels. This case lends further debate to the issue of whether antithrombin concentrate, in addition to anticoagulation, should be routinely administered for venous thromboembolic prophylaxis during pregnancy and the puerperium to women with inherited antithrombin deficiency. This point may become more relevant as further experience is gained with the use of recombinant human antithrombin.
Christopher J Sharpe; Mark A Crowther; Kathryn E Webert; Cara Donnery
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion medicine reviews     Volume:  25     ISSN:  1532-9496     ISO Abbreviation:  Transfus Med Rev     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709027     Medline TA:  Transfus Med Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.
McMaster University, Hamilton, Ontario, Canada.
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