Document Detail

Cerebral venous thrombosis and activated protein C resistance.
MedLine Citation:
PMID:  8841319     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Activated protein C resistance (APC-R) due to factor V Leiden has recently been established as an important risk factor for cerebral venous thrombosis (CVT). The clinical significance of abnormal or borderline functional APC-R in the absence of factor V Leiden is uncertain. Our observations suggest that APC-R due to mechanisms other than factor V Leiden may also contribute to the development of CVT. CASE DESCRIPTIONS: We describe three women who had superior sagittal and lateral sinus thrombosis while taking oral contraceptives and had a number of additional risk factors for CVT. Each had APC-R for different reasons. CONCLUSIONS: Inherited thrombophilia, including APC-R, should be looked for in all patients with CVT. Functional APC-R is a highly prevalent coagulopathy, but the reasons for this abnormality are diverse; abnormal and borderline functional APC-R results should be supplemented by DNA analysis for the presence of factor V Leiden.
D A Dulli; C C Luzzio; E C Williams; H S Schutta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  27     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-15     Completed Date:  1996-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1731-3     Citation Subset:  IM    
Department of Neurology, University of Wisconsin-Madison Medical School 53792, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Cerebral Veins
Contraceptives, Oral / adverse effects
Drug Resistance
Intracranial Embolism and Thrombosis / drug therapy,  physiopathology*
Partial Thromboplastin Time
Protein C / analysis,  physiology*
Protein S / analysis
Risk Factors
Sinus Thrombosis, Intracranial / drug therapy,  etiology,  physiopathology
Warfarin / therapeutic use
Reg. No./Substance:
0/Anticoagulants; 0/Contraceptives, Oral; 0/Protein C; 0/Protein S; 81-81-2/Warfarin
Comment In:
Stroke. 1996 Oct;27(10):1719-20   [PMID:  8841316 ]

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