Document Detail


Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment.
MedLine Citation:
PMID:  19877794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral venous sinus thrombosis (CVST) is a rare clinicopathological entity. The incidence of CVST in children and neonates has been reported to be as high as 7 cases per million people, whereas in adults the incidence is 3-4 cases per million. The predisposing factors to this condition are mainly genetic and acquired prothrombotic states and infection. The clinical picture of CVST is nonspecific, highly variable, and can mimic several other clinical conditions. Diagnosis of CVST is established with the implementation of neuroimaging studies, especially MR imaging and venography. Identification and elimination of the underlying cause, anticoagulation, proper management of intracranial hypertension, and anticonvulsant prophylaxis constitute cornerstones of CVST treatment. Newer treatment strategies such as endovascular thrombolysis and decompressive craniectomy have been recently used in the treatment of patients with CVST with variable success rates. Further clinical research must be performed to delineate the exact role of these newer treatments in the management of severe cases of CVST. The recent advances in the diagnosis and treatment of patients with CVST have significantly lowered the associated mortality and morbidity and have improved the outcome of these patients.
Authors:
Aristotelis Filippidis; Eftychia Kapsalaki; Gianna Patramani; Kostas N Fountas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgical focus     Volume:  27     ISSN:  1092-0684     ISO Abbreviation:  Neurosurg Focus     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2009-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896471     Medline TA:  Neurosurg Focus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E3     Citation Subset:  IM    
Affiliation:
Departments of Neurosurgery, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / therapeutic use
Cerebral Angiography
Cerebral Veins / anatomy & histology,  radiography
Clinical Protocols
Contraceptives, Oral / adverse effects
Craniotomy
Diagnosis, Differential
Female
Humans
Intracranial Hypertension / etiology,  surgery
Magnetic Resonance Imaging
Middle Aged
Neurosurgical Procedures / methods
Prognosis
Sinus Thrombosis, Intracranial / diagnosis*,  physiopathology,  therapy*
Thrombolytic Therapy / methods
Tissue Plasminogen Activator / therapeutic use
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Contraceptives, Oral; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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