Document Detail

Cerebral vasospasm.
MedLine Citation:
PMID:  2225095     Owner:  NLM     Status:  MEDLINE    
Cerebral vasospasm (specifically, intracranial arterial spasm) is variously defined as: (1) an arteriographically evident narrowing of the lumen of one or more of the major intracranial arteries at the base of the brain due to contraction of the smooth muscle within the arterial wall, or due to the morphological changes in the arterial wall and along its endothelial surface that occur in response to vessel injury; (2) the delayed onset of a neurological deficit following subarachnoid hemorrhage, thought to be due to ischemia or infarction of a portion of the brain; or (3) the combination of these two features (symptomatic vasospasm). The arterial contraction of intracranial arterial spasm typically develops a few days after the rupture of an intracranial aneurysm and lasts 2 to 3 weeks. Such arterial spasm can also occur in other conditions such as head trauma. If it is severe enough it can lead to cerebral infarction. The pathogenesis of this condition is still unclear. Many ingenious attempts have been made to prevent or treat cerebral vasospasm, but most have failed. The best current approach is to ensure adequate blood volume, and to elevate the patient's blood pressure (especially if the aneurysm has been secured by an early operation). The continuing investigation of drugs such as calcium channel blocking agents to improve the cerebral circulation has begun to provide additional help.
R H Wilkins
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in neurobiology     Volume:  6     ISSN:  0892-0915     ISO Abbreviation:  Crit Rev Neurobiol     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-19     Completed Date:  1990-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710803     Medline TA:  Crit Rev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-77     Citation Subset:  IM    
Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Cerebral Arteries / physiopathology
Intracranial Aneurysm / physiopathology
Ischemic Attack, Transient / physiopathology*,  therapy

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