Document Detail


Cerebral vasospasm.
MedLine Citation:
PMID:  2225095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral vasospasm (specifically, intracranial arterial spasm) is variously defined as: (1) an arteriographically evident narrowing of the lumen of one or more of the major intracranial arteries at the base of the brain due to contraction of the smooth muscle within the arterial wall, or due to the morphological changes in the arterial wall and along its endothelial surface that occur in response to vessel injury; (2) the delayed onset of a neurological deficit following subarachnoid hemorrhage, thought to be due to ischemia or infarction of a portion of the brain; or (3) the combination of these two features (symptomatic vasospasm). The arterial contraction of intracranial arterial spasm typically develops a few days after the rupture of an intracranial aneurysm and lasts 2 to 3 weeks. Such arterial spasm can also occur in other conditions such as head trauma. If it is severe enough it can lead to cerebral infarction. The pathogenesis of this condition is still unclear. Many ingenious attempts have been made to prevent or treat cerebral vasospasm, but most have failed. The best current approach is to ensure adequate blood volume, and to elevate the patient's blood pressure (especially if the aneurysm has been secured by an early operation). The continuing investigation of drugs such as calcium channel blocking agents to improve the cerebral circulation has begun to provide additional help.
Authors:
R H Wilkins
Related Documents :
17947595 - Noninvasive detection of diffuse intracranial disease.
16922075 - Intracranial aneurysm following radiation therapy during childhood for a brain tumor. c...
13943015 - Cerebral angiography. its use in acute head injuries and undiagnosed coma.
9481195 - Cryptococcosis at the university hospital, kuala lumpur.
20733875 - Patents.
21704975 - Evaluation of the vertebrobasilar system in thoracic aortic surgery.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in neurobiology     Volume:  6     ISSN:  0892-0915     ISO Abbreviation:  Crit Rev Neurobiol     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-19     Completed Date:  1990-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710803     Medline TA:  Crit Rev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-77     Citation Subset:  IM    
Affiliation:
Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Arteries / physiopathology
Humans
Intracranial Aneurysm / physiopathology
Ischemic Attack, Transient / physiopathology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of opioid peptides on peripheral stimulation and "stress"-induced analgesia in animals.
Next Document:  Determination of gestational age by ultrasound