Document Detail

Cerebral vasospasm in conditions other than subarachnoid hemorrhage.
MedLine Citation:
PMID:  2136145     Owner:  NLM     Status:  MEDLINE    
Intracranial arterial spasm is an arteriographically evident narrowing of the lumen of one or more of the major intracranial arteries at the base of the brain that develops in some patients 1 or more days after the rupture of an intracranial aneurysm. If it is severe enough, such cerebral vasospasm may be accompanied by cerebral ischemia or infarction. Because of its usual setting, cerebral vasospasm is thought to arise from some chemical factor or factors in the blood that accumulates within the basal subarachnoid cisterns and bathes the arteries that subsequently develop spasm. There seem to be exceptions to this basic plan, however. In patients with a ruptured aneurysm, only some of the arteries bathed in subarachnoid blood develop spasm. Of more significance, some patients develop intracranial arterial spasm without apparent subarachnoid bleeding. Until the development of CT scanning, the evidence for the lack of subarachnoid hemorrhage in such patients was weak. We now have the ability to assess cerebral vasospasm repetitively in a noninvasive manner with TCD ultrasonography and to quantitate subarachnoid hemorrhage by CT scanning. We should take advantage of this opportunity to document cases that are exceptions to the rule. Does hypothalamic damage explain such cases, or is there some other explanation? This question may be the key for unlocking the mysteries of the pathogenesis of cerebral vasospasm.
R H Wilkins
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery clinics of North America     Volume:  1     ISSN:  1042-3680     ISO Abbreviation:  Neurosurg. Clin. N. Am.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1992-08-19     Completed Date:  1992-08-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9008004     Medline TA:  Neurosurg Clin N Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
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MeSH Terms
Brain Injuries / complications,  diagnosis
Cerebral Angiography
Hypothalamic Diseases / complications,  diagnosis
Intracranial Aneurysm / surgery
Ischemic Attack, Transient / diagnosis,  etiology*
Postoperative Complications / diagnosis,  etiology
Subarachnoid Hemorrhage / complications,  diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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