Document Detail


Cerebral vasoreactivity and the prediction of outcome in severe traumatic brain lesions.
MedLine Citation:
PMID:  1902616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mean hemispheric blood flow (CBF) was studied in 38 comatose, severely brain-injured patients following intravenous administration of xenon-133. Repeated measurements were performed in order to evaluate cerebral vasoreactivity following a decrease in PaCO2. Simultaneously, arterial-venous oxygen differences (AVDO2) and intracranial pressure (ICP) were measured. An impaired CBF response to hyperventilation (delta CBF/delta PaCO2 less than 1.0) was obtained in 22 patients. Three of 16 patients with preserved CO2-reactivity died because of their brain injuries and 12 patients reached good recovery/moderate disability. In the group of patients with impaired vasoreactivity 11 of 22 patients died and only three patients reached good recovery/moderate disability. The study documents that in patients with severe traumatic brain lesions measurements of cerebral vasoreactivity to hyperventilation give prognostic information that is not obtained by clinical observations or CT-scanning.
Authors:
W Schalén; K Messeter; C H Nordström
Related Documents :
17490686 - Mri brain lesion patterns in patients in anoxia-induced vegetative state.
12623496 - Presence of post-concussion syndrome symptoms in patients with chronic pain vs mild tra...
10563626 - Leukoencephalopathy and raised brain lactate from heroin vapor inhalation ("chasing the...
9109866 - A new leukoencephalopathy with vanishing white matter.
18334236 - Cognitive impairment in the aging dialysis and chronic kidney disease populations: an o...
15543326 - Compensated activation of coagulation in patients with abdominal aortic aneurysm: effec...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  35     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-31     Completed Date:  1991-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University Hospital of Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity
Brain / metabolism
Brain Injuries / complications,  metabolism,  physiopathology*
Carbon Dioxide / metabolism
Cerebrovascular Circulation / physiology*
Coma / etiology,  physiopathology*
Humans
Hyperemia / etiology
Intracranial Pressure
Oxygen / metabolism
Prognosis
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Generation of arachidonic acid metabolites from stimulated whole blood in patients with chronic myel...
Next Document:  Effects of acute alterations in left ventricular loading conditions on peak filling rate in the dene...