Document Detail

Cerebral vasoreactivity and the prediction of outcome in severe traumatic brain lesions.
MedLine Citation:
PMID:  1902616     Owner:  NLM     Status:  MEDLINE    
Mean hemispheric blood flow (CBF) was studied in 38 comatose, severely brain-injured patients following intravenous administration of xenon-133. Repeated measurements were performed in order to evaluate cerebral vasoreactivity following a decrease in PaCO2. Simultaneously, arterial-venous oxygen differences (AVDO2) and intracranial pressure (ICP) were measured. An impaired CBF response to hyperventilation (delta CBF/delta PaCO2 less than 1.0) was obtained in 22 patients. Three of 16 patients with preserved CO2-reactivity died because of their brain injuries and 12 patients reached good recovery/moderate disability. In the group of patients with impaired vasoreactivity 11 of 22 patients died and only three patients reached good recovery/moderate disability. The study documents that in patients with severe traumatic brain lesions measurements of cerebral vasoreactivity to hyperventilation give prognostic information that is not obtained by clinical observations or CT-scanning.
W Schalén; K Messeter; C H Nordström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  35     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-31     Completed Date:  1991-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  113-22     Citation Subset:  IM    
Department of Neurosurgery, University Hospital of Lund, Sweden.
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MeSH Terms
Blood Flow Velocity
Brain / metabolism
Brain Injuries / complications,  metabolism,  physiopathology*
Carbon Dioxide / metabolism
Cerebrovascular Circulation / physiology*
Coma / etiology,  physiopathology*
Hyperemia / etiology
Intracranial Pressure
Oxygen / metabolism
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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