Document Detail

Cerebral vasoreactivity in Andeans and headache at sea level.
MedLine Citation:
PMID:  15050445     Owner:  NLM     Status:  MEDLINE    
Headache is common in Cerro de Pasco (CP), Peru (altitude 4338 m) and was present in all patients with chronic mountain sickness (CMS) in CP reported here. Forty-seven percent of inhabitants report headache. Twenty-four percent of men have migraine with aura, with an average of 65 attacks a year. We assessed vasoreactivity of the cerebral vessels to CO2 by rebreathing and to NO by the administration of isosorbite dinitrate (IDN), a nitric oxide (NO) donor, using transcranial Doppler ultrasound in the middle cerebral artery (MCA) in natives of CP, some of whom suffered from CMS. We repeated the measurements in Lima (altitude 150 m) in the same subjects within 24 h of arrival. Vasodilatation in the middle cerebral artery supply territory in response to CO2 and NO, both physiologic vasodilators, is defective in Andean natives at altitude and in the same subjects at sea level. Incapacitating migraine can occur with impaired cerebral vasoreactivity to physiologic vasodilators. We propose that susceptibility to migraine might depend in part on gene expression with consequent alterations of endothelial function.
O Appenzeller; C Passino; R Roach; J Gamboa; A Gamboa; L Bernardi; M Bonfichi; L Malcovati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  219     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-06-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
NMHEMC Research Foundation, Otto Appenzeller, 361, Big Horn Ridge Drive NE, Albuquerque, NM 87122-1424, USA.
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MeSH Terms
Altitude Sickness / metabolism,  physiopathology*,  ultrasonography
Carbon Dioxide / metabolism
Cerebrovascular Circulation / physiology*
Chronic Disease
Middle Cerebral Artery / physiology,  ultrasonography
Migraine with Aura / metabolism,  physiopathology*,  ultrasonography
Nitric Oxide / metabolism
Ultrasonography, Doppler, Transcranial
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide

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