| Cerebral vasoreactivity in Andeans and headache at sea level. | |
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MedLine Citation:
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PMID: 15050445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Headache is common in Cerro de Pasco (CP), Peru (altitude 4338 m) and was present in all patients with chronic mountain sickness (CMS) in CP reported here. Forty-seven percent of inhabitants report headache. Twenty-four percent of men have migraine with aura, with an average of 65 attacks a year. We assessed vasoreactivity of the cerebral vessels to CO2 by rebreathing and to NO by the administration of isosorbite dinitrate (IDN), a nitric oxide (NO) donor, using transcranial Doppler ultrasound in the middle cerebral artery (MCA) in natives of CP, some of whom suffered from CMS. We repeated the measurements in Lima (altitude 150 m) in the same subjects within 24 h of arrival. Vasodilatation in the middle cerebral artery supply territory in response to CO2 and NO, both physiologic vasodilators, is defective in Andean natives at altitude and in the same subjects at sea level. Incapacitating migraine can occur with impaired cerebral vasoreactivity to physiologic vasodilators. We propose that susceptibility to migraine might depend in part on gene expression with consequent alterations of endothelial function. |
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Authors:
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O Appenzeller; C Passino; R Roach; J Gamboa; A Gamboa; L Bernardi; M Bonfichi; L Malcovati |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 219 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-30 Completed Date: 2004-06-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 101-6 Citation Subset: IM |
Affiliation:
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NMHEMC Research Foundation, Otto Appenzeller, 361, Big Horn Ridge Drive NE, Albuquerque, NM 87122-1424, USA. ottoarun12@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Altitude* Altitude Sickness / metabolism, physiopathology*, ultrasonography Carbon Dioxide / metabolism Cerebrovascular Circulation / physiology* Chronic Disease Humans Male Middle Cerebral Artery / physiology, ultrasonography Migraine with Aura / metabolism, physiopathology*, ultrasonography Nitric Oxide / metabolism Peru Ultrasonography, Doppler, Transcranial |
| Grant Support | |
ID/Acronym/Agency:
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IHSEP-02/HS/AHRQ HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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