Document Detail

Cerebral vasomotor reactivity in epilepsy patients.
MedLine Citation:
PMID:  20037764     Owner:  NLM     Status:  MEDLINE    
Vasomotor reactivity, which can be defined as the cerebral vasculature response to hypoxia, is not well known in epilepsy patients. We aimed to evaluate cerebrovascular reserve in idiopathic generalized epilepsy patients using transcranial Doppler ultrasonography (TCD). The study included 20 patients and 20 healthy volunteers. Diagnosis of epilepsy was based on the observation of seizure in the video electroencephalography unit. Cerebrovascular reactivity was evaluated by means of the breath-holding index. Insonation depth and basal velocity were symmetrical and not significantly different between the two groups (p[0.05). The breath-holding index ranged from 0.62 to 4.45 (mean 2.13 +/- 0.83) in the epilepsy patients and 0.57 to 2.55 (mean 1.60 +/- 0.46) in the control group (p\0.05). Breath-holding index values showed that cerebrovascular reserve in epilepsy patients was increased, as compared to healthy individuals. Cerebrovascular reserve was increased in epilepsy patients; this should not be accepted as an abnormality, but might have been the result of an adaptive mechanism that protects the brain from hypoxic challenges due to seizure apnea.
Semai Bek; Tayfun Kaşikçi; Güray Koç; Gençer Genç; Seref Demirkaya; Zeki Gökçil; Zeki Odabaşi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  257     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-12     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  833-8     Citation Subset:  IM    
Department of Neurology, Gulhane Medical Faculty, 06018 Etlik-Ankara, Turkey.
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MeSH Terms
Blood Flow Velocity
Brain / blood supply,  physiopathology*
Cerebrovascular Circulation / physiology*
Electroencephalography / methods
Epilepsy / diagnosis,  physiopathology*,  ultrasonography
Middle Cerebral Artery / physiopathology
Seizures / diagnosis,  physiopathology,  ultrasonography
Ultrasonography, Doppler, Transcranial
Video Recording / methods
Young Adult
Comment In:
J Neurol. 2010 Sep;257(9):1565   [PMID:  20339861 ]

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