Document Detail

Cerebral vasculitis and unilateral sixth-nerve palsy in acute post-streptococcal glomerulonephritis.
MedLine Citation:
PMID:  18510827     Owner:  NLM     Status:  MEDLINE    
Cerebral vasculitis associated with acute post-streptococcal glomerulonephritis (APSGN) is rare. A 13-year-old girl presented with severe headache, vomiting, oedema and macroscopic haematuria. There was a history of upper respiratory infection 2 weeks previously. A diagnosis of APSGN was made. On admission, she was normotensive and biochemically well balanced. She experienced a tonic-clonic seizure 2 hours later. An MRI brain scan demonstrated multiple areas of abnormal signal intensity in the cerebral and cerebellar white matter, and subarachnoid haemorrhage consistent with vasculitis was diagnosed. A sixth-nerve palsy developed on the 6th day of admission. An elevated anti-streptolysin titre and low serum C3 complement level together with typical features on renal biopsy supported the diagnosis of APSGN. All clinical and laboratory abnormalities improved with corticosteroid therapy, pulse methyl-prednisolone. APSGN can present with central nervous system abnormalities without hypertension, uraemia and electrolyte disturbance.
Ismail Dursun; Zubeyde Gunduz; Hakan M Poyrazoglu; Hakan Gumus; Ali Yikilmaz; Ruhan Dusunsel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  28     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-30     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Paediatric Nephrology, Erciyes University, Kayseri, Turkey.
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MeSH Terms
Abducens Nerve Diseases / diagnosis,  microbiology*
Acute Disease
Glomerulonephritis / complications*,  microbiology
Magnetic Resonance Imaging
Streptococcal Infections / complications*
Vasculitis, Central Nervous System / diagnosis,  microbiology*

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